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5-HT2C receptor agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (100) Adrenergic Receptor (4) Androgen Receptor (1) Apoptosis (3) Calcium Channel (1) Dopamine Receptor (20) Dopamine Transporter (1) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (7) GABA Receptor (1) HCN Channel (2) Hedgehog (1) Interleukin Related (1) Isotope-Labeled Compounds (9) Melatonin Receptor (9) Monoamine Oxidase (1) Parasite (1) Phosphatase (1) Potassium Channel (2) Reference Standards (14) Serotonin Transporter (3) Sigma Receptor (1) Smo (2) Sodium Channel (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (7) Metabolic Disease (11) Neurological Disease (89)

By Targets:

5-HT Receptor (100)

Adrenergic Receptor (4)

Androgen Receptor (1)

Apoptosis (3)

Calcium Channel (1)

Dopamine Receptor (20)

Dopamine Transporter (1)

Drug Derivative (1)

Drug Metabolite (2)

Endogenous Metabolite (7)

GABA Receptor (1)

HCN Channel (2)

Hedgehog (1)

Interleukin Related (1)

Isotope-Labeled Compounds (9)

Melatonin Receptor (9)

Monoamine Oxidase (1)

Parasite (1)

Phosphatase (1)

Potassium Channel (2)

Reference Standards (14)

Serotonin Transporter (3)

Sigma Receptor (1)

Smo (2)

Sodium Channel (1)

STAT (1)

TNF Receptor (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (3)

Infection (3)

Inflammation/Immunology (7)

Metabolic Disease (11)

Neurological Disease (89)

103

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19545A

SCH-23390 hydrochloride Maximum Cited Publications 31 Publications Verification R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM .

HY-14546

Aripiprazole 10+ Cited Publications OPC-14597	5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, *5-HT2C, D3, and D4 receptors*. Aripiprazole can be used for the research of schizophrenia and COVID19 .

HY-14544

Quetiapine 3 Publications Verification ICI204636	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, **5-HT2C receptor with pK_i**s of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-103124

DOI hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
DOI hydrochloride is a serotonin 5-HT_2A/_2C receptor agonist with K_i values of 0.7 nM, 2.4 nM and 20 nM for h5-HT_2A, h5-HT_2C and h5-HT_2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice .

HY-17038

Agomelatine Maximum Cited Publications 9 Publications Verification S-20098	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-156601

Bexicaserin LP352	5-HT Receptor	Neurological Disease
Bexicaserin (LP352) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related disorders (such as epilepsy) .

HY-N0049

Nuciferine 5+ Cited Publications	Parasite 5-HT Receptor Dopamine Receptor	Neurological Disease
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-32329

Setiptiline Org-8282	5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-B0031

Quetiapine hemifumarate 3 Publications Verification	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, **5-HT2C receptor with pK_i**s of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-14153

Tegaserod 4 Publications Verification	5-HT Receptor Apoptosis	Metabolic Disease Cancer
Tegaserod is an orally active *serotonin receptor* 4 (HTR4; 5-HT₄R*) agonist* and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-14153A

Tegaserod maleate 4 Publications Verification SDZ-HTF-919; HTF-919	5-HT Receptor Apoptosis	Neurological Disease Metabolic Disease Cancer
Tegaserod maleate (SDZ-HTF-919) is an orally active *serotonin receptor* 4 (HTR4; 5-HT₄R*) agonist* and a 5-HT_2B receptor antagonist. Tegaserod maleate has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-14546A

Aripiprazole monohydrate 10+ Cited Publications OPC-14597 monohydrate	5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, *5-HT2C, D3, and D4 receptors*. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19 .

HY-N0247

Saikosaponin B1 2 Publications Verification	Hedgehog Smo STAT Interleukin Related TNF Receptor	Inflammation/Immunology Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the **5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer** activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-101341

RS 67333 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
RS 67333 hydrochloride is a potent and selective *5-HT4 receptor* (5-HT4R)** partial agonist with a pK_i of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research .

HY-111200

Vabicaserin hydrochloride 4 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) *receptor*-selective agonist with an EC₅₀ of 8 nM.

HY-103138

(Rac)-WAY-161503 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity **5-HT_2C receptor** agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects .

HY-15543A

CP-809101 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
CP-809101 hydrochloride is a potent and highly selective *5-HT_2C* receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human *5HT_2C, 5HT_2B* and 5HT_2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence .

HY-W050162

(E)-3,4,5-Trimethoxycinnamic acid 1 Publications Verification TMCA	GABA Receptor 5-HT Receptor	Neurological Disease
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABA_A/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to *5-HT_2C* and 5-HT_1A receptor, with IC₅₀ values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy .

HY-101630

Deramciclane EGIS-3886	5-HT Receptor	Neurological Disease
Deramciclane has a high affinity for 5-HT_2A and *5-HT_2C* receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT_2C receptors without direct stimulatory agonist.

HY-16687A

Eltoprazine hydrochloride DU 28853 hydrochloride	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a **5-HT2C receptor** antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects .

HY-100330

YM348 1 Publications Verification	5-HT Receptor	Metabolic Disease
YM348 is a potent and orally active **5-HT_2C receptor** agonist, which shows a high affinity for cloned human **5-HT_2C receptor (K_i**: 0.89 nM).

HY-123838

Ro60-0175	5-HT Receptor	Neurological Disease
Ro60-0175 is a potent and selective agonist of *5-HT_2C* receptor. Ro60-0175 reduces self-administration .

HY-133113

7-Desmethyl-agomelatine 1 Publications Verification	5-HT Receptor	Neurological Disease
7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C .

HY-103138A

(Rac)-WAY-161503 1 Publications Verification	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity **5-HT_2C receptor** agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects .

HY-153912

5-HT2A receptor agonist-3	5-HT Receptor	Neurological Disease
5-HT2A receptor agonist-3 ((S,S)-9b) is a 5-HT2A receptor agonist with a K_i of 2.5 nM for human 5-HT2A receptor. 5-HT2A receptor agonist-3 shows 124-fold selectivity for 5-HT2A over the structurally similar **5-HT2C receptor** .

HY-132225

SB 206553	5-HT Receptor	Inflammation/Immunology
SB 206553 is a 5-HT_2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT_2A), 7.7 nM (5-HT_2B) and 7.8 nM (5-HT_2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders .

HY-14544R

Quetiapine (Standard) ICI204636 (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine (Standard) is the analytical standard of Quetiapine. This product is intended for research and analytical applications. Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, **5-HT2C receptor with pK_i**s of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031R

Quetiapine hemifumarate (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine (hemifumarate) (Standard) is the analytical standard of Quetiapine (hemifumarate). This product is intended for research and analytical applications. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, **5-HT2C receptor with pK_i**s of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-133024

Flumexadol	5-HT Receptor	Neurological Disease
Flumexadol is a selective and affinity **5-HT_2C receptor** agonist with a K_i of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT_2A receptor. Flumexadol is an orally active non-narcotic analgesic .

HY-121920

25C-NBOH hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
25C-NBOH hydrochloride is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine and is a potent agonist of 5-HT receptors that shows selectivity for 5-HT2A over 5-HT2C (EC₅₀s = ~ 0.40 and 15 nM, respectively) .

HY-32329A

Setiptiline maleate MO-8282	5-HT Receptor	Neurological Disease
Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT_2A, 5-HT_2C, and/or 5-HT₃ subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-175515

5-HT2C agonist-11	5-HT Receptor	Neurological Disease
5-HT2C agonist-11 (Compound 1) is an orally active, brain-penetrant and selective **5-HT_2C receptor** agonist (EC₅₀=15 nM). 5-HT2C agonist-11 activates the Gq protein signaling pathway, promoting intracellular calcium release. 5-HT2C agonist-11 is promising for research of depression, post-traumatic stress disorder (PTSD) and neuropathic pain .

HY-17038A

Agomelatine hydrochloride Maximum Cited Publications 9 Publications Verification S-20098 hydrochloride	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-16687

Eltoprazine DU 28853	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a **5-HT2C receptor** antagonist. Eltoprazine shows antiaggressive and anxiogenic effects .

HY-17038S2

Agomelatine-d3 S-20098-d₃	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .

HY-145841

5-HT2A receptor agonist-2	5-HT Receptor	Cardiovascular Disease
5-HT2A receptor agonist-2 is a highly potent serotonin 5-HT2 receptor agonists. 5-HT2A receptor agonist-2 inspires 5-HT_2A, 5-HT_2B, and 5-HT_2C with EC₅₀ values of 1.7, 0.58, and 0.50 nM, respectively .

HY-14546R

Aripiprazole (Standard) OPC-14597 (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (Standard) is the analytical standard of Aripiprazole. This product is intended for research and analytical applications. Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, *5-HT2C, D3, and D4 receptors*. Aripiprazole can be used for the research of schizophrenia and COVID19 .

HY-178760

TGF-8027	5-HT Receptor	Neurological Disease
TGF-8027 is a selective 5-HT_2A agonist that can cross the blood-brain barrier. TGF-8027 exhibits EC₅₀s of 3.3 nM, 160 nM and 7600 nM against human 5-HT_2A, *5-HT_2C* and 5-HT_2B and exhibits EC₅₀s against mouse 5-HT_2A and mouse 5-HT_2C of 14 and 210 nM. TGF-8027 can induce a head-shaking response in mice. TGF-8027 can be used to study diseases that target the 5-HT_2A receptor (such as depression) .

HY-14546S

Aripiprazole-d8 OPC-14597-d₈	5-HT Receptor	Neurological Disease
Aripiprazole-d₈ (OPC-14597-d₈) is the deuterium labeled Aripiprazole (HY-14546). Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

HY-15401

WAY 163909	5-HT Receptor	Neurological Disease Metabolic Disease
WAY 163909 is an orally active, blood-brain barrier permeable *5-HT2C* receptor-selective agonist. WAY 163909 exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

HY-124947

PF-4522654	5-HT Receptor	Neurological Disease
PF-4522654 is a potent, selective and brain-permeable **5-HT_2C receptor** agonist with an EC₅₀ of 16 nM and a K_i of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT_2A and 5-HT_2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI) .

HY-106136

TIK-301 PD-6735; LY-156735	Melatonin Receptor 5-HT Receptor	Neurological Disease
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT₁ and MT₂ receptors agonist with K_is of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a **5-HT_2B/5-HT_2C receptors** antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .

HY-156532C

(-)-5-HT2C agonist-3	5-HT Receptor	Neurological Disease
(-)-5-HT2C agonist-3 (compound (-)-19) is a *5-HT_2C* selective agonist with G_q signaling preference, with EC₅₀ values for 5-HT₂ receptors of *5-HT_2C: 103 nM; 5-HT_2B: 570 nM; 5-HT_2A: 72 nM. (-)-5-HT2C* agonist-3 can be used in antipsychotic research .

HY-167677

ASP-2205	5-HT Receptor	Neurological Disease
ASP-2205 is a *5-HT_2C* receptor agonist (human *5-HT_2C* receptor, EC₅₀=0.85 nM; rat *5-HT_2C* receptor, EC₅₀=2.5 nM). ASP-2205 enhances the pudendal nerve-mediated urethral closure reflex through the *5-HT_2C* receptor, thereby preventing urinary incontinence .

HY-103140

Ro60-0175 fumarate	5-HT Receptor	Neurological Disease
Ro60-0175 fumarate is a potent and selective agonist of *5-HT_2C* receptor .

HY-100171

PRX933 hydrochloride GW876167 hydrochloride; BVT-933 hydrochloride	5-HT Receptor	Cardiovascular Disease
PRX933 hydrochloride is a **5-HT_2c receptor** agonist extracted from patent WO 2014140631 A1.

HY-A0172

Captodiame Captodiamine	5-HT Receptor Dopamine Receptor Sigma Receptor	Neurological Disease
Captodiame (Captodiamine) is a **5-HT_2c receptor antagonist and sigma-1** and D3 dopamine receptor agonist. Captodiame shows antidepressant effect .

HY-119103

PF-03246799	5-HT Receptor	Neurological Disease
PF-03246799 is a potent and selective **5-HT2C receptor** agonist with an EC₅₀ of 190 nM and a K_i of 160 nM. PF-03246799 shows selectivity for 5-HT2C over 5-HT2A and 5-HT2B receptors. PF-03246799 has the potential for stress urinary incontinence (SUI) research .

HY-116524

PF-04781340	5-HT Receptor	Neurological Disease
PF-04781340 is a potent and selective **5-HT2C receptor** agonist. PF-04781340 is orally available and have central nervous system penetrant profile .

HY-17038B

Agomelatine (L(+)-Tartaric acid) Maximum Cited Publications 9 Publications Verification S-20098 L(+)-Tartaric acid	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

Cat. No.	Product Name	Type

HY-15401A

WAY 163909 (hydrochloride)

Biochemical Assay Reagents

WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17038

Agomelatine Maximum Cited Publications 9 Publications Verification S-20098	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-N0049

Nuciferine 5+ Cited Publications	Alkaloids Aporphine Alkaloids other families Plants Isoquinoline Alkaloids Source Classification	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N0247

Saikosaponin B1 2 Publications Verification	Structural Classification Classification of Application Fields Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification Cancer	Hedgehog Smo STAT Interleukin Related TNF Receptor
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the **5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer** activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-17038A

Agomelatine hydrochloride Maximum Cited Publications 9 Publications Verification S-20098 hydrochloride	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-17038B

Agomelatine (L(+)-Tartaric acid) Maximum Cited Publications 9 Publications Verification S-20098 L(+)-Tartaric acid	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-N8200

Cassiaside B2	Monophenols Classification of Application Fields Phenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Inflammation/Immunology Disease Research Fields Source Classification	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a *5-HT2C* receptor agonist . ..

HY-17038R

Agomelatine (Standard) S-20098 (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-17038AR

Agomelatine hydrochloride (Standard) S-20098 hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Melatonin Receptor 5-HT Receptor Endogenous Metabolite Reference Standards
Agomelatine (hydrochloride) (Standard) is the analytical standard of Agomelatine (hydrochloride). This product is intended for research and analytical applications. Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .

HY-N0247R

Saikosaponin B1 (Standard)	Structural Classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the *5-HT_2C* receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-N0049R

Nuciferine (Standard)	Alkaloids other families Plants Source Classification	Reference Standards 5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Cat. No.	Product Name	Chemical Structure

HY-W052508S

Norquetiapine-d8

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-17038S2

Agomelatine-d3
Agomelatine-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .

HY-14546S

Aripiprazole-d8

Aripiprazole-d₈ (OPC-14597-d₈) is the deuterium labeled Aripiprazole (HY-14546). Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

HY-17038S1

Agomelatine-d4
Agomelatine-d₄ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-176436S

GW-117
GW-117 is a **5-HT2C receptor** antagonist and a melatonin (MT1/MT2) receptor agonist. GW-117 shows antidepressant-like and anxiolytic-like effects .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate . Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-14544AS

Quetiapine-d4 hydrochloride

Quetiapine-d₄ (hydrochloride) (ICI204636-d₄ (hydrochloride)) is deuterium labeled Quetiapine. Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

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