2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (R,S)-MDMA

(R,S)-MDMA acts as a partial agonist of 5-HT2A, 5-HT2B and 5-HT2C receptors. (R,S)-MDMA belongs to psychoactive substances. (R,S)-MDMA exhibits antidepressant activity. (R,S)-MDMA can be used for research on mental disorders such as post-traumatic stress disorder and depression.

For research use only. We do not sell to patients.

(R,S)-MDMA

(R,S)-MDMA Chemical Structure

CAS No. : 859811-50-0

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Other Forms of (R,S)-MDMA:

(R,S)-MDMA Related Antibodies

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Description

(R,S)-MDMA acts as a partial agonist of 5-HT2A, 5-HT2B and 5-HT2C receptors. (R,S)-MDMA belongs to psychoactive substances. (R,S)-MDMA exhibits antidepressant activity. (R,S)-MDMA can be used for research on mental disorders such as post-traumatic stress disorder and depression[1].

IC50 & Target[1]

5-HT2B Receptor

52.2 nM (Kd)

5-HT2C Receptor

158 nM (EC50)

5-HT2A Receptor

249 nM (EC50)

In Vitro

(R,S)-MDMA (55 min) acts as a partial agonist of 5-HT2A, 5-HT2B, and 5-HT2C receptors in HEK293T cells, with EC50 values of 249 nM, 52.2 nM, and 158 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R,S)-MDMA Related Antibodies
In Vivo

(R,S)-MDMA (7.5 mg/kg; intraperitoneal injection; single administration) enhances sociability in C57BL/6J mice in the three-chamber social interaction test[1].
Administration of (R,S)-MDMA (7.5 mg/kg; i.p.) during training induces significant social conditioned place preference in C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (9-13 weeks old)[1]
Dosage: 7.5 mg/kg
Administration: i.p.; single dose
Result: Increased social interaction compared to vehicle controls over the 25-min exploration period.
Showed the largest difference in prosocial behavior compared to vehicle during the final 10 min of the 30-min assay.
Molecular Weight

192.25

Formula

C12H16O2
CAS No.
SMILES

CC(CC1=CC2=C(C=C1)OCO2)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R,S)-MDMA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,S)-MDMA859811-50-05-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorHEK293T cellssocial conditioned place preference5-HT2B receptors3-chamber social interaction assayserotonin5-HT2C receptors5-HT2A receptorsC57BL/6J miceInhibitorinhibitorinhibit

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