1. GPCR/G Protein
    Neuronal Signaling
  2. Melatonin Receptor
    5-HT Receptor
  3. TIK-301

TIK-301 (Synonyms: PD-6735; LY-156735)

Cat. No.: HY-106136
Handling Instructions

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.

For research use only. We do not sell to patients.

TIK-301 Chemical Structure

TIK-301 Chemical Structure

CAS No. : 118702-11-7

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Description

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].

IC50 & Target

melatonin MT1

0.081 nM (Ki)

melatonin MT2

0.042 nM (Ki)

5-HT2C Receptor

 

5-HT2B Receptor

 

In Vivo

In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake[1][2].
The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

280.75

Formula

C₁₄H₁₇ClN₂O₂

CAS No.

118702-11-7

SMILES

CC(NC[[email protected]@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TIK-301PD-6735 LY-156735TIK301TIK 301PD6735PD 6735LY156735LY 156735LY-156735Melatonin Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMelatoninMT1MT25-HT2B5-HT2CinsomniasedativechlorinatedantidepressantInhibitorinhibitorinhibit

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Product Name:
TIK-301
Cat. No.:
HY-106136
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