118702-11-7
Chemical Structure
TIK-301
Synonym(s): PD-6735; LY-156735
- CAS No.: 118702-11-7
- Formula:C14H17ClN2O2
- Molecular Weight:280.75
IUPAC Name: (R)-N-(2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl)acetamide
InChIKey: RKHCTAKUYDTFHE-QMMMGPOBSA-N
SMILES: CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O
Biological Activity: TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].
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TIK-301 | TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment. | |||||||||||||||||||||
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- [1]. Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21(11):1661-78. [Content Brief]
- [2]. Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68. [Content Brief]
- [3]. Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37. [Content Brief]
Keywords
