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CYB210010

CYB210010 is an orally bioavailable, long-acting serotonin 5-HT2 receptor agonist that selectively targets 5-HT2A and 5-HT2C receptors (EC₅₀: 4.1 n, 7.3 nM). CYB210010 can enter the central nervous system, cause a head twitch response (HTR), and is not prone to behavioral tolerance during chronic administration.

For research use only. We do not sell to patients.

CAS No.: 2762568-47-6
Formula: C₁₁H₁₅ClF₃NO₂S
Molecular Weight:317.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CYB210010 Chemical Structure

CAS No.: 2762568-47-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT_2C Receptor

5-HT_1A Receptor

32 nM (Ki)

5-HT_1B Receptor

949 nM (Ki)

5-HT₆ Receptor

1301 nM (Ki)

5-HT₇ Receptor

4918 nM (Ki)

5-HT_2A Receptor

4.1 nM (EC₅₀)

5-HT_2C Receptor

7.3 nM (EC₅₀)

5-HT_2B Receptor

88 nM (EC₅₀)

All 5-HT Receptor Isoforms :

In Vivo

CYB210010 has certain oral bioavailability and can smoothly enter the central nervous system, bind to 5-HT2A receptors in the frontal cortex, and increase the expression of neuroplasticity-related genes in the frontal cortex^[1].
CYB210010 (0.1-3 mg/kg; sc; single dose) causes a head twitch response (HTR) in mouse, and can be administered subchronically at threshold doses without developing behavioral tolerance^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice^[1]
Dosage:

0.1, 0.3, 1, 3, mg/kg
Administration:

sc; sigle dose
Result:

Elicited maximum HTRs at ∼15 min postadministration which terminated after 220 min (significant from vehicle from 5-160 min).

Chemical Information

CAS No. 2762568-47-6
Molecular Weight 317.76
Formula C₁₁H₁₅ClF₃NO₂S
SMILES

COC1=C(CCN)C=C(OC)C(SC(F)(F)F)=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Varty GB, et al. Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist. J Med Chem. 2024 Apr 25;67(8):6144-6188. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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