1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Quetiapine-d8 fumarate

Quetiapine-d8 fumarate 

Cat. No.: HY-B0031S2
Handling Instructions

Quetiapine-d8 fumarate is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

For research use only. We do not sell to patients.

Quetiapine-d8 fumarate Chemical Structure

Quetiapine-d8 fumarate Chemical Structure

CAS No. : 1185247-12-4

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Description

Quetiapine-d8 fumarate is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

507.63

Formula

C25H21D8N3O6S

CAS No.
SMILES

OC(/C=C/C(O)=O)=O.OCCOCCN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C2=NC3=CC=CC=C3SC4=CC=CC=C24

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Quetiapine-d8 fumarate
Cat. No.:
HY-B0031S2
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