CP-809101 hydrochloride
Based on 2 publication(s) in Google Scholar
CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.
For research use only. We do not sell to patients.
- Purity: 98.61%
- CAS No.: 1215721-40-6
- Formula: C15H18Cl2N4O
- Molecular Weight:341.24
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) CP-809101 hydrochloride
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
5-HT2C Receptor 9.96 (pEC50) |
5-HT2B Receptor 7.19 (pEC50) |
5-HT2A Receptor 6.81 (pEC50) |
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED50 value of 2.2 mg/kg[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CF rats (conditioned avoidance responding (CAR) model)[1].
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Dosage:0.1-56 mg/kg
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Administration:Subcutaneous injection; single.
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Result:Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID50 value of 4.8 mg/kg.
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Animal Model:Male CD rats (PCP or d-amphetamine-induced hyperactivity model)[1].
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Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
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Administration:Subcutaneous injection; single.
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Result:Antagonized PCP-induced hyperactivity, with an ED50 value of 2.4 mg/kg.
Antagonized d-amphetamine-induced hyperactivity, with an ED50 value of 2.7 mg/kg, and in a dose-dependent manner.
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Animal Model:Male CD rats (spontaneous locomotor model)[1].
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Dosage:0.56, 1.78, 5.6, 17.8 mg/kg
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Administration:Subcutaneous injection; single.
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Result:Inhibited spontaneous locomotor activity in a dose-dependent manner (ED50=2.7 mg/kg).
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Animal Model:Adult male Sprague-Dawley rats (280-400 g)[2].
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Dosage:0.3, 1, 3 mg/kg
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Administration:Subcutaneous injection; single.
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Result:Produced a dose-related decrease in responding for food and nicotine self-administration in rats.
Chemical Information
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CAS No. 1215721-40-6
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Appearance Solid
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Molecular Weight 341.24
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Formula C15H18Cl2N4O
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Color Light yellow to yellow
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SMILES
[H]Cl.ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Brain
Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours. [Abstract]2024 Nov 4;147(11):3764-3779. PMID: 38701344 -
Solvent & Solubility
H2O : 20 mg/mL (58.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. [Content Brief]
[2]. Higgins GA, et al. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9305 mL | 14.6524 mL | 29.3049 mL | 73.2622 mL |
| 5 mM | 0.5861 mL | 2.9305 mL | 5.8610 mL | 14.6524 mL | |
| 10 mM | 0.2930 mL | 1.4652 mL | 2.9305 mL | 7.3262 mL | |
| 15 mM | 0.1954 mL | 0.9768 mL | 1.9537 mL | 4.8841 mL | |
| 20 mM | 0.1465 mL | 0.7326 mL | 1.4652 mL | 3.6631 mL | |
| 25 mM | 0.1172 mL | 0.5861 mL | 1.1722 mL | 2.9305 mL | |
| 30 mM | 0.0977 mL | 0.4884 mL | 0.9768 mL | 2.4421 mL | |
| 40 mM | 0.0733 mL | 0.3663 mL | 0.7326 mL | 1.8316 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5861 mL | 1.4652 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CP-809101 hydrochloride Related Classifications
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