1215721-40-6
Chemical Structure
CP-809101 hydrochloride
- CAS No.: 1215721-40-6
- Formula:C15H18Cl2N4O
- Molecular Weight:341.24
IUPAC Name: 2-((3-chlorobenzyl)oxy)-6-(piperazin-1-yl)pyrazine hydrochloride
InChIKey: NMUNRTCTDLORDR-UHFFFAOYSA-N
SMILES: [H]Cl.ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1
Biological Activity: CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].
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CP-809101 hydrochloride | 98.61% | CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence. | ||||||||||||||||||||
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- [1]. Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. [Content Brief]
- [2]. Higgins GA, et al. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. [Content Brief]
Keywords
