1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Ro60-0175 fumarate

Ro60-0175 fumarate 

Cat. No.: HY-103140 Purity: 99.47%
COA Handling Instructions

Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor.

For research use only. We do not sell to patients.

Ro60-0175 fumarate Chemical Structure

Ro60-0175 fumarate Chemical Structure

CAS No. : 169675-09-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 495 In-stock
5 mg USD 450 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ro60-0175 fumarate:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor[1].

IC50 & Target[1]

5-HT2C Receptor


In Vivo

Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].
Ro60-0175 (0.3, 1, and? 3 mg/kg (Ro60-0175); 1?mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].
Ro60-0175 (0.5 mg/kg (SB242084); 1?mg/kg (Ro60-0175); 1?mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment[1].
Ro60-0175 (0.3, 1, and?3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group[1].
Ro60-0175 (0.5?mg/kg SB242084; 1?mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







N[[email protected]@H](C)CN1C=CC2=C1C=C(Cl)C(F)=C2.OC(/C=C/C(O)=O)=O


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (291.76 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9176 mL 14.5879 mL 29.1758 mL
5 mM 0.5835 mL 2.9176 mL 5.8352 mL
10 mM 0.2918 mL 1.4588 mL 2.9176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
Ro60-0175 fumarate
Cat. No.:
MCE Japan Authorized Agent: