1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Ro60-0175 fumarate

Ro60-0175 fumarate 

Cat. No.: HY-103140
Handling Instructions

Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 fumarate reduces Cocaine self-administration, and the ability of Cocaine to reinstate responding after extinction of drug-seeking behavior.

For research use only. We do not sell to patients.

Ro60-0175 fumarate Chemical Structure

Ro60-0175 fumarate Chemical Structure

CAS No. : 169675-09-6

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Description

Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 fumarate reduces Cocaine self-administration, and the ability of Cocaine to reinstate responding after extinction of drug-seeking behavior[1].

IC50 & Target[1]

5-HT2C Receptor

 

In Vivo

Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].
Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); s.c., i.p.) fumarate reduces responding for cocaine and effect is reversed by SB242084[1].
Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].
Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment[1].
Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group[1].
Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.75

Formula

C15H16ClFN2O4

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Ro60-0175 fumarate
Cat. No.:
HY-103140
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