Ro60-0175 fumarate 

Ro60-0175 fumarate is a potent and selective agonist of 5-HT_2C receptor^[1].

Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier^[1].
Ro60-0175 (0.3, 1, and? 3 mg/kg (Ro60-0175); 1?mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection^[1].
Ro60-0175 (0.5 mg/kg (SB242084); 1?mg/kg (Ro60-0175); 1?mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment^[1].
Ro60-0175 (0.3, 1, and?3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group^[1].
Ro60-0175 (0.5?mg/kg SB242084; 1?mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

342.75

Solid

C₁₅H₁₆ClFN₂O₄

169675-09-6

N[[email protected]@H](C)CN1C=CC2=C1C=C(Cl)C(F)=C2.OC(/C=C/C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412.  [Content Brief]