Org-12962 hydrochloride
Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
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- No. CAS: 210821-63-9
- Fòrmula: C10H12Cl2F3N3
- Peso molecular:302.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
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5-HT2A Receptor 6.38 (pEC50) |
5-HT2C Receptor 7.01 (pEC50) |
5-HT2B Receptor 6.28 (pEC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3]
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Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
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Administration:Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
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Result:Had a dose-related antipanic-like effect in SD-rat.
Chemical Information
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No. CAS 210821-63-9
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Peso molecular 302.12
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Fòrmula C10H12Cl2F3N3
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SMILES
FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [Content Brief]
[2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [Content Brief]
[3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Org-12962 hydrochloride Related Classifications
HY-21994 Related Classifications
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