1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Org-12962 hydrochloride

Org-12962 hydrochloride 

Cat. No.: HY-21994
Handling Instructions

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.

For research use only. We do not sell to patients.

Org-12962 hydrochloride Chemical Structure

Org-12962 hydrochloride Chemical Structure

CAS No. : 210821-63-9

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Org-12962 hydrochloride:

Other Forms of Org-12962 hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].

IC50 & Target[1][2]

5-HT2C Receptor

7.01 (pEC50)

5-HT2A Receptor

6.38 (pEC50)

5-HT2B Receptor

6.28 (pEC50)

In Vivo

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

Animal Model: Male Wistar rats[3]
Dosage: 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration: Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result: Had a dose-related antipanic-like effect in SD-rat.
Molecular Weight

302.12

Formula

C₁₀H₁₂Cl₂F₃N₃

CAS No.

210821-63-9

SMILES

FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Org-12962Org12962Org 129625-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorpanicantiaversivebrainbarrierpermeabilityBBBInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Org-12962 hydrochloride
Cat. No.:
HY-21994
Quantity:
MCE Japan Authorized Agent: