1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Org-12962

Org-12962 

Cat. No.: HY-118152 Purity: >98.0%
Handling Instructions

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.

For research use only. We do not sell to patients.

Org-12962 Chemical Structure

Org-12962 Chemical Structure

CAS No. : 132834-56-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].

IC50 & Target

5-HT2C Receptor

7.01 (pEC50)

5-HT2A Receptor

6.38 (pEC50)

5-HT2B Receptor

6.28 (pEC50)

In Vivo

Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)[1].

Animal Model: Male Wistar rats[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3.2 mg/kg
Administration: Intraperitoneal injection; 0.3-3.2 mg/kg
Result: Induced a dose-related antipanic-like effect.
Molecular Weight

265.66

Formula

C₁₀H₁₁ClF₃N₃

CAS No.

132834-56-1

SMILES

FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (941.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7642 mL 18.8210 mL 37.6421 mL
5 mM 0.7528 mL 3.7642 mL 7.5284 mL
10 mM 0.3764 mL 1.8821 mL 3.7642 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (8.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (8.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (8.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Org-12962Org12962Org 129625-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorpanicantiaversivebrainbarrierpermeabilityBBBInhibitorinhibitorinhibit

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Product name:
Org-12962
Cat. No.:
HY-118152
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