132834-56-1
132834-56-1
Chemical Structure
Org-12962
- CAS No.: 132834-56-1
- Formula:C10H11ClF3N3
- Molecular Weight:265.66
IUPAC Name: 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine
InChIKey: QZYYPQAYSFBKPW-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl
Biological Activity: Org-12962 is a potent, selective and brain-penetrant and 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].
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Org-12962 | 99.93% | Org-12962 is a potent, selective and brain-penetrant and 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. | ||||||||||||||||||||
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References
- [1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [Content Brief]
- [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [Content Brief]
- [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22. [Content Brief]
Keywords
