(-)-5-HT2C agonist-3
Based on 1 Customer Validation
(-)-5-HT2C agonist-3 (compound (-)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research.
For research use only. We do not sell to patients.
- CAS No.: 2104810-16-2
- Formula: C19H23ClFNO2
- Molecular Weight:351.84
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
|
5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
5-HT2A Receptor 72 nM (IC50) |
5-HT2C Receptor 103 nM (IC50) |
5-HT2B Receptor 570 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
103 nM
Compound: (-)-19
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Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
|
[PMID: 28657744] |
| HEK293 | EC50 |
570 nM
Compound: (-)-19
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Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
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[PMID: 28657744] |
| HEK293 | EC50 |
72 nM
Compound: (-)-19
|
Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
|
[PMID: 28657744] |
Chemical Information
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CAS No. 2104810-16-2
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Appearance Solid
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Molecular Weight 351.84
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Formula C19H23ClFNO2
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SMILES
COC(C=CC=C1)=C1CNC[C@H]2[C@H](C3=C(C=CC(F)=C3)OC)C2.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (284.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8422 mL | 14.2110 mL | 28.4220 mL | 71.0550 mL |
| 5 mM | 0.5684 mL | 2.8422 mL | 5.6844 mL | 14.2110 mL | |
| 10 mM | 0.2842 mL | 1.4211 mL | 2.8422 mL | 7.1055 mL | |
| 15 mM | 0.1895 mL | 0.9474 mL | 1.8948 mL | 4.7370 mL | |
| 20 mM | 0.1421 mL | 0.7106 mL | 1.4211 mL | 3.5528 mL | |
| 25 mM | 0.1137 mL | 0.5684 mL | 1.1369 mL | 2.8422 mL | |
| 30 mM | 0.0947 mL | 0.4737 mL | 0.9474 mL | 2.3685 mL | |
| 40 mM | 0.0711 mL | 0.3553 mL | 0.7106 mL | 1.7764 mL | |
| 50 mM | 0.0568 mL | 0.2842 mL | 0.5684 mL | 1.4211 mL | |
| 60 mM | 0.0474 mL | 0.2369 mL | 0.4737 mL | 1.1843 mL | |
| 80 mM | 0.0355 mL | 0.1776 mL | 0.3553 mL | 0.8882 mL | |
| 100 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7106 mL |
(-)-5-HT2C agonist-3 Related Classifications
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