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Results for "

P-388 leukemia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (1) Antibiotic (28) Apoptosis (4) Arp2/3 Complex (1) Bacterial (28) Calcium Channel (1) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (5) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (3) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fungal (5) HIV (3) HSP (1) iGluR (1) MetAP (1) PKC (1) Proteasome (3) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Somatostatin Receptor (1) Topoisomerase (5)
By Research Areas:	Cancer (65) Cardiovascular Disease (2) Infection (37) Inflammation/Immunology (1) Neurological Disease (1)

By Targets:

Aminopeptidase (1)

Antibiotic (28)

Apoptosis (4)

Arp2/3 Complex (1)

Bacterial (28)

Calcium Channel (1)

CDK (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (5)

Drug Derivative (4)

Drug Intermediate (1)

Drug Isomer (1)

Endogenous Metabolite (3)

Environmental Pollutants (1)

Estrogen Receptor/ERR (1)

Farnesyl Transferase (1)

Fungal (5)

HIV (3)

HSP (1)

iGluR (1)

MetAP (1)

PKC (1)

Proteasome (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

Somatostatin Receptor (1)

Topoisomerase (5)

By Research Areas:

Cancer (65)

Cardiovascular Disease (2)

Infection (37)

Inflammation/Immunology (1)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Targets Recommended: BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2306

Aclacinomycin A 5 Publications Verification Aclarubicin	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N3308

Medicarpin 2 Publications Verification	Apoptosis	Cancer
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .

HY-N0128

Sclareol 3 Publications Verification	Environmental Pollutants Apoptosis	Cancer
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-120504

N-Acetyltyramine 1 Publications Verification	Bacterial	Infection Cancer
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .

HY-N2306A

Aclacinomycin A hydrochloride Aclarubicin hydrochloride	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-105172

TT-232 CAP-232; TLN-232	Somatostatin Receptor	Inflammation/Immunology Cancer
TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent .

HY-N6065

Praeruptorin A 3 Publications Verification (+)-Praeruptorin A	Calcium Channel Drug Isomer Cytochrome P450 iGluR Apoptosis	Cardiovascular Disease Neurological Disease
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .

HY-103653

CKD-731	MetAP	Cardiovascular Disease Cancer
CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer .

HY-108603

Bryostatin 2 (+)-Bryostatin 2	PKC	Cancer
Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic leukemia .

HY-N2306R

Aclacinomycin A (Standard) Aclarubicin (Standard)	Reference Standards Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-12458

Pyrindamycin A	DNA/RNA Synthesis	Infection Cancer
Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC₅₀ of 3.9 μg/ml .

HY-125037

Diptoindonesin G	Estrogen Receptor/ERR HSP	Cancer
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC₅₀ of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer .

HY-121123

Adamantanine 2-Aminoadamantane-2-carboxylic acid	Aminopeptidase	Cancer
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5 .

HY-118726

Luotonin F	Topoisomerase	Cancer
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

HY-114648

AJI-9561	Bacterial	Infection Cancer
AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJI-9561 exhibits cytotoxicity and antibacterial activity. AJI-9561 inhibits the proliferation of Jurkat T cells and mouse P388 leukemia cells, with its IC₅₀ being 0.88 and 1.63 μM respectively. AJI-9561 can be used for research on anti-cancer and antibacterial properties .

HY-117783

Y-05460M-A	Antibiotic	Infection
Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .

HY-N0128R

Sclareol (Standard)	Reference Standards Apoptosis	Cancer
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N13941

Baciphelacin	Bacterial	Infection Cancer
Baciphelacin is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells .

HY-113771

Saquayamycin C	Bacterial	Infection Cancer
Saquayamycin C has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13870

Saquayamycin A1	Bacterial	Infection Cancer
Saquayamycin A1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin A1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13868

Saquayamycin C1	Bacterial	Infection Cancer
Saquayamycin C1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N14621

Harzialacton A	Others	Cancer
Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED₅₀ of > 100 μg/mL .

HY-N13878

Anguinomycin B	Antibiotic Bacterial	Infection
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .

HY-N14720

Demethylolivomycin A	Antibiotic Bacterial	Infection Cancer
Demethylolivomycin A is an antitumor antibiotic. Demethylolivomycin A has anti-Gram-positive bacteria and anti-leukemia P388 activity .

HY-126170

Valanimycin	Antibiotic Bacterial	Infection Cancer
Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC₅₀ of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice .

HY-N14522

Gilvocarcin E	Bacterial	Infection Cancer
Gilvocarcin E has anti-Gram-positive bacterial activity and can inhibit sarcoma 180 and P388 leukemia cells .

HY-P2045

RA-VII	Arp2/3 Complex	Cancer
RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma .

HY-129752

Piperafizine B	Antibiotic	Cancer
Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC₅₀s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model .

HY-135137

Leptosin I	Others	Cancer
Leptosin I is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin I inhibits Leukemia lymphocyte P388 in culture with an ED₅₀ of 1.13 μg/mL .

HY-N13894

Auramycin A	Antibiotic Bacterial	Infection Cancer
Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N14303

16-Methyloxazolomycin	Antibiotic Bacterial	Infection Cancer
16-Methyloxazolomycin is an antibiotic. 16-Methyloxazolomycin has the effect of resisting bacteria and algae. 16-Methyloxazolomycin against leukemia P388 and human lung adenocarcinoma cells .

HY-12459

Pyrindamycin B	Bacterial	Infection
Pyrindamycin B is an antibiotic, actives against gram-positive and gram-negative bacterias, and exhibits strong therapeutic effects against both agent-sensitive and resistant cells of P388 leukemia in mice .

HY-N14019

Glidobactin B	Antibiotic Bacterial	Infection Cancer
Glidobactin B is an anti-tumor antibiotic. Glidobactin B has the activity against pathogenic fungi and yeast. Glidobactin B also extends the survival of mice inoculated with leukemia P388 cells .

HY-N14023

Glidobactin G	Antibiotic Fungal	Infection Cancer
Glidobactin G is an anti-tumor antibiotic. Glidobactin G has the activity against pathogenic fungi and yeast. Glidobactin G also extends the survival of mice inoculated with leukemia P388 cells .

HY-N14022

Glidobactin F	Antibiotic Fungal	Infection Cancer
Glidobactin F is an anti-tumor antibiotic. Glidobactin F has the activity against pathogenic fungi and yeast. Glidobactin F also extends the survival of mice inoculated with leukemia P388 cells .

HY-N13895

Auramycin B	Antibiotic Bacterial	Infection Cancer
Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-N14095

Curromycin A	Bacterial HIV	Infection Cancer
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-N14496

Nisamycin	Bacterial	Infection Cancer
Nisamycin has stronger anti-Gram-positive bacteria and weaker anti-fungal and individual Gram-negative bacteria activities. Nisamycin has weak cytotoxic effect. The IC₅₀ of mouse leukemia P388 cells is 4.8 μg/mL .

HY-N14110

Curromycin B	Bacterial HIV	Infection
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-167671

BE-10988	Topoisomerase	Cancer
BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes .

HY-N18237

Bruceanol A	Others	Cancer
Bruceanol A is an antileukemic quassinoid glycoside isolated from Brucea javanica. Bruceanol A exhibits antileukemic activity against P-388 lymphocytic leukemia in vivo. Bruceanol A can be used in studies related to P-388 lymphocytic leukemia .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N1649

2,3,2'',3''-Tetrahydroochnaflavone	Others	Cancer
2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC₅₀ of 8.2 µg/mL .

HY-126695

Altromycin B	Antibiotic	Infection
Altromycin B is a member of the pluramycin antibiotic family isolated from South African bush soil. Altromycin B shows selective antibacterial activity against Gram-positive bacteria and has in vivo activity against P388 leukemia, colon cancer, lung cancer, and ovarian cancer.

HY-123325

Kapurimycin A1	Antibiotic Bacterial	Infection Cancer
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .

HY-N14959

Deacetylravidomycin N-oxide	Antibiotic Bacterial	Infection Cancer
Deacetylravidomycin N-oxide is an antibiotic that can be produced by Streptomyces ravidus S50905. Deacetylravidomycin N-oxide is active against Gram-positive bacteria but inactive against Gram-negative bacteria. Deacetylravidomycin N-oxide has antitumor activity against P388 leukemia and methamphetamine A fibrosarcoma .

HY-N5186

Cypemycin	Antibiotic Bacterial	Infection Cancer
Cypemycin is a linaridin antibiotic that can inhibit cancer cell activity, inhibits P388 leukemia cells with IC₅₀ of 1.3 μg/mL. Cypemycin can inhibit human tumor cells such as HeLa S3, HHCC-1, HCCS-M and Slex with IC₅₀ of >25 μg/mL .

HY-137139

10'-Desmethoxystreptonigrin	Antibiotic Bacterial Farnesyl Transferase	Infection Cancer
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC₅₀ of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-113578

PD 116152	Antibiotic Bacterial	Infection Cancer
PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC₅₀ values of 5.2 x 10 ^-7 M and 7.1 x 10 ^-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia .

Cat. No.	Product Name	Type

HY-N2306R

Aclacinomycin A (Standard)

Aclarubicin (Standard)

Fluorescent Dyes

Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

Cat. No.	Product Name	Target	Research Area

HY-105172

TT-232 CAP-232; TLN-232	Somatostatin Receptor	Inflammation/Immunology Cancer
TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent .

HY-P2045

RA-VII	Arp2/3 Complex	Cancer
RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma .

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-P11338

Microcyclamide	Endogenous Metabolite	Cancer
Microcyclamide (Compound 1), a cytotoxic cyclic hexapeptide, is a microbial secondary metabolite. Microcyclamide can be isolated from the cyanobacterium Microcystis aeruginosa. Microcyclamide has moderate cytotoxicity against P388 murine leukemia cells with an IC₅₀ of 1.2 μg/mL. Microcyclamide can be used for cancers research .

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