2. Cell Cycle/DNA Damage
  3. CDK
  4. BMS-357075

BMS-357075 is a pan-CDK inhibitor with CDK1 IC50 18 nM, CDK2 IC50 3 nM, CDK4 IC50 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia.

For research use only. We do not sell to patients.

BMS-357075

BMS-357075 Chemical Structure

CAS No. : 350509-99-8

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BMS-357075 Related Antibodies

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Description

BMS-357075 is a pan-CDK inhibitor with CDK1 IC50 18 nM, CDK2 IC50 3 nM, CDK4 IC50 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia[1].

IC50 & Target[1]

CDK1/cyclinB1

18 nM (IC50)

CDK2/cyclinE

3 nM (IC50)

CDK4/cyclin D

26 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
3 nM
Compound: 19
Cytotoxic effect on human ovarian (A2780) cancer cell line
Cytotoxic effect on human ovarian (A2780) cancer cell line
[PMID: 15125971]
In Vitro

BMS-357075 (compound 19) potently inhibits CDK1/cyclin B (IC50 = 18 nM), CDK2/cyclin E (IC50 = 3 nM), and CDK4/cyclin D (IC50 = 26 nM) in cell-free enzyme assays[1].
BMS-357075 potently inhibits the viability of human ovarian cancer A2780 cells with an IC50 of 3 nM[1].
BMS-357075 shows 90% protein binding in mouse serum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-357075 Related Antibodies
In Vivo

BMS-357075 (compound 19) (4 mg/kg; i.p.; once daily; 7 days) produces a 56% increase in survival time (%T/C = 156) against P388 murine leukemia in immunocompetent mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

461.64

Formula

C22H31N5O2S2
CAS No.
SMILES

OCC(C)(CNCC1=CN=C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)C=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-357075 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-357075350509-99-8BMS357075BMS 357075CDKCyclin dependent kinaseCDK2cyclin ECDK4cyclin Dimmunocompetent miceP388 murine leukemiahuman ovarian cancer A2780 cellsmouse serumcyclin BCDK1Inhibitorinhibitorinhibit

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