BMS-357075
BMS-357075 is a pan-CDK inhibitor with CDK1 IC50 18 nM, CDK2 IC50 3 nM, CDK4 IC50 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 350509-99-8
- Formula: C22H31N5O2S2
- Molecular Weight:461.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK1/cyclinB1 18 nM (IC50) |
CDK2/cyclinE 3 nM (IC50) |
CDK4/cyclin D 26 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3 nM
Compound: 19
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Cytotoxic effect on human ovarian (A2780) cancer cell line
Cytotoxic effect on human ovarian (A2780) cancer cell line
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[PMID: 15125971] |
BMS-357075 (compound 19) potently inhibits CDK1/cyclin B (IC50 = 18 nM), CDK2/cyclin E (IC50 = 3 nM), and CDK4/cyclin D (IC50 = 26 nM) in cell-free enzyme assays[1].
BMS-357075 potently inhibits the viability of human ovarian cancer A2780 cells with an IC50 of 3 nM[1].
BMS-357075 shows 90% protein binding in mouse serum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 350509-99-8
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Molecular Weight 461.64
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Formula C22H31N5O2S2
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SMILES
OCC(C)(CNCC1=CN=C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)C=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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