Diptoindonesin G
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer.
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- No. CAS: 1190948-58-3
- Fòrmula: C21H12O6
- Peso molecular:360.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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HSP90 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| P388 | IC50 |
13.2 μM
Compound: Diptoindonesin G
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Cytotoxicity against mouse P388 cells assessed as growth inhibition
Cytotoxicity against mouse P388 cells assessed as growth inhibition
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[PMID: 28318943] |
Chemical Information
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No. CAS 1190948-58-3
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Peso molecular 360.32
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Fòrmula C21H12O6
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SMILES
O=C1C2=C3C(OC(C4=CC=C(O)C=C4)=C3C5=C1C(O)=CC(O)=C5)=CC(O)=C2
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Juliawaty LD, et al. A 2-arylbenzofuran derivative from Hopea mengarawan. Nat Prod Commun. 2009 Jul;4(7):947-50. [Content Brief]
[2]. Liu JT, et al. Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors. Org Biomol Chem. 2016 Sep 26;14(38):8927-8930. [Content Brief]
[3]. Donahue K, et al. Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment. J Biol Chem. 2022 Dec;298(12):102700. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diptoindonesin G Related Classifications
HY-125037 Related Classifications
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