BE-10988
BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes.
For research use only. We do not sell to patients.
- CAS No.: 135261-89-1
- Formula: C13H10N4O3S
- Molecular Weight:302.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | IC50 |
8.7 μM
Compound: 1
|
The IC50 value was measured on human breast cancer cell line SK-BR-3.
The IC50 value was measured on human breast cancer cell line SK-BR-3.
|
[PMID: 7699696] |
| V79 | IC50 |
5.1 μM
Compound: 1
|
The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.
The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.
|
[PMID: 7699696] |
| V79 | IC50 |
6.2 μM
Compound: 1
|
The IC50 value was measured on V79 cells in the presence of air using MTT assay.
The IC50 value was measured on V79 cells in the presence of air using MTT assay.
|
[PMID: 7699696] |
Chemical Information
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CAS No. 135261-89-1
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Molecular Weight 302.31
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Formula C13H10N4O3S
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SMILES
O=C(C1=CSC(C2=CN(C)C(C(C=C3N)=O)=C2C3=O)=N1)N
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Structure Classification
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Initial Source
Actinomycetes
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)