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Results for "

bronchial asthma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Payload (2) Adenosine Receptor (1) Adrenergic Receptor (30) Amyloid-β (5) Angiotensin Receptor (1) Antibiotic (4) Apoptosis (2) Bacterial (7) Biochemical Assay Reagents (1) Calcium Channel (1) CCR (1) Cholinesterase (ChE) (3) Drug Isomer (1) Endogenous Metabolite (7) Enterovirus (2) ERK (7) Glucocorticoid Receptor (2) GSK-3 (5) Histamine Receptor (12) Influenza Virus (3) Interleukin Related (5) Isotope-Labeled Compounds (11) Leukotriene Receptor (1) mAChR (9) MMP (1) Natriuretic Peptide Receptor (NPR) (1) Neurokinin Receptor (1) NF-κB (6) Parasite (4) PARP (1) Phosphodiesterase (PDE) (3) PI3K (1) Platelet-activating Factor Receptor (PAFR) (1) Prostaglandin Receptor (4) Reactive Oxygen Species (ROS) (1) Reference Standards (16) Ser/Thr Protease (2) TNF Receptor (4)
By Research Areas:	Cancer (20) Cardiovascular Disease (18) Endocrinology (18) Infection (13) Inflammation/Immunology (67) Metabolic Disease (13) Neurological Disease (10)

By Targets:

5-HT Receptor (4)

ADC Payload (2)

Adenosine Receptor (1)

Adrenergic Receptor (30)

Amyloid-β (5)

Angiotensin Receptor (1)

Antibiotic (4)

Apoptosis (2)

Bacterial (7)

Biochemical Assay Reagents (1)

Calcium Channel (1)

CCR (1)

Cholinesterase (ChE) (3)

Drug Isomer (1)

Endogenous Metabolite (7)

Enterovirus (2)

ERK (7)

Glucocorticoid Receptor (2)

GSK-3 (5)

Histamine Receptor (12)

Influenza Virus (3)

Interleukin Related (5)

Isotope-Labeled Compounds (11)

Leukotriene Receptor (1)

mAChR (9)

MMP (1)

Natriuretic Peptide Receptor (NPR) (1)

Neurokinin Receptor (1)

NF-κB (6)

Parasite (4)

PARP (1)

Phosphodiesterase (PDE) (3)

PI3K (1)

Platelet-activating Factor Receptor (PAFR) (1)

Prostaglandin Receptor (4)

Reactive Oxygen Species (ROS) (1)

Reference Standards (16)

Ser/Thr Protease (2)

TNF Receptor (4)

By Research Areas:

Cancer (20)

Cardiovascular Disease (18)

Endocrinology (18)

Infection (13)

Inflammation/Immunology (67)

Metabolic Disease (13)

Neurological Disease (10)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 87 Publications Verification Isoproterenol hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1037

Salbutamol 5+ Cited Publications Albuterol; AH-3365	Adrenergic Receptor ERK	Inflammation/Immunology Cancer
Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-A0083

Methacholine chloride 5+ Cited Publications Acetyl-β-methylcholine chloride	mAChR	Others
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

HY-B0320A

Cromolyn disodium 5+ Cited Publications Cromoglycate disodium; Cromoglicic acid disodium; FPL-670	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-17360

Tiotropium Bromide 2 Publications Verification BA679 BR	mAChR	Inflammation/Immunology
Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-A0062

Telithromycin 5 Publications Verification HMR3647; RU66647	Bacterial Antibiotic	Infection Inflammation/Immunology
Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .

HY-108353

Isoprenaline Maximum Cited Publications 87 Publications Verification	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-P2232

Conalbumin Ovotransferrin	Bacterial	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone .

HY-B0436

Salbutamol hemisulfate 5+ Cited Publications Albuterol hemisulfate; AH-3365 hemisulfate	Adrenergic Receptor ERK	Inflammation/Immunology Cancer
Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-Y0912

HBTU N-HBTU	Biochemical Assay Reagents	Inflammation/Immunology
HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma .

HY-B0010

Formoterol fumarate 5+ Cited Publications (±)Formoterol fumarate	Adrenergic Receptor	Inflammation/Immunology
Formoterol fumarate ((±)Formoterol fumarate) is a selective β₂-adrenoceptor agonist. Formoterol fumarate is at least as β₂-adrenoceptor selective as Salbutamol (HY-B1037) and Terbutaline (HY-B0802A). Formoterol fumarate abolishs the contraction induced by Acetylcholine in bronchioles. Formoterol fumarate can be used for the research of chronic obstructive pulmonary disease and bronchial asthma .

HY-B1810

Tulobuterol 2 Publications Verification C-78 free base	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Tulobuterol (C-78 free base) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

HY-12642

Diethylcarbamazine citrate 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine citrate is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine citrate reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine citrate reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine citrate enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine citrate can be used for the researches of bronchial asthma, insulin resistance and infection .

HY-16768

Fevipiprant 1 Publications Verification QAW039; NVP-QAW039	Prostaglandin Receptor	Cardiovascular Disease
Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an K_d value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .

HY-B1619

Cromolyn 5+ Cited Publications Cromoglycate; Cromoglicic acid; FPL-670 free acid	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B0154

Fluticasone propionate 1 Publications Verification	Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (K_D) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-14300A

Vilanterol trifenatate 5+ Cited Publications GW642444 trifenatate	Adrenergic Receptor	Inflammation/Immunology Endocrinology Cancer
Vilanterol (GW642444) trifenatate is a long-acting β₂ adrenergic receptor agonist. Vilanterol trifenatate has pEC₅₀ values for β₂-AR, β₁-AR, and β₃-AR of 9.4, 6.4, and 6.1, respectively. Vilanterol trifenatate selectively activates airway β₂ adrenergic receptors, increases cAMP and thus relaxes bronchial smooth muscle. Vilanterol trifenatate can be used in asthma research ^[2][4].

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB	Inflammation/Immunology Cancer
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

HY-B1589A

Carbinoxamine maleate salt 1 Publications Verification	Histamine Receptor Influenza Virus	Infection Inflammation/Immunology
Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.

HY-B0538A

Pemirolast potassium TWT-8152; BMY 26517	Histamine Receptor	Cardiovascular Disease Inflammation/Immunology
Pemirolast potassium is an orally active antiallergic agent. Pemirolast potassium attenuates Paclitaxel (HY-B0015) hypersensitivity reactions. Pemirolast potassium can be used for bronchial asthma and conjunctivitis research ^- .

HY-15485

Zardaverine 1 Publications Verification	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC₅₀)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma .

HY-14300

Vilanterol 5+ Cited Publications GW642444	Adrenergic Receptor	Inflammation/Immunology Endocrinology Cancer
Vilanterol (GW642444) is a long-acting β₂adrenergic receptor agonist. Vilanterol has pEC₅₀ values for β₂-AR, β₁-AR, and β₃-AR of 9.4, 6.4, and 6.1, respectively. Vilanterol selectively activates airway β₂ adrenergic receptors, increases cAMP and thus relaxes bronchial smooth muscle. Vilanterol can be used in asthma research ^[3][5].

HY-B0460

Tiotropium bromide monohydrate 2 Publications Verification BA-679 BR monohydrate	mAChR	Inflammation/Immunology
Tiotropium bromide monohydrate (BA-679 BR monohydrate) is a long-acting anticholinergic bronchodilator. Tiotropium bromide monohydrate blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide monohydrate is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-W011733

Tulobuterol hydrochloride 2 Publications Verification C-78	Adrenergic Receptor Influenza Virus Antibiotic	Infection Inflammation/Immunology Endocrinology
Tulobuterol hydrochloride (C-78) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength . Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation .

HY-17360S1

Tiotropium-d6 bromide BA679 BR-d₆	Isotope-Labeled Compounds mAChR	Neurological Disease
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-12642A

Diethylcarbamazine 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection .

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

HY-B1037S

Salbutamol-d3 Albuterol-d₃; AH-3365-d₃	Isotope-Labeled Compounds ERK Adrenergic Receptor	Inflammation/Immunology Cancer
Salbutamol-d₃ (Albuterol-d₃) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-B1037S2

Salbutamol-d9 Albuterol-d₉; AH-3365-d₉	Isotope-Labeled Compounds ERK Adrenergic Receptor	Inflammation/Immunology Cancer
Salbutamol-d₉ (Albuterol-d₉) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-P991278

ABM-125	Interleukin Related	Inflammation/Immunology
ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations .

HY-B1347

Clorprenaline hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Clorprenaline hydrochloride is a β₂-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-109544

Repirinast MY-5116	Histamine Receptor	Inflammation/Immunology
Repirinast (MY-5116) is an orally active anti-allergic agent. Repirinast inhibits histamine release. Repirinast can be used in the research of bronchial asthma .

HY-18706

trans-Tranilast trans-MK-341; trans-SB 252218	Angiotensin Receptor Drug Isomer	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
trans-Tranilast (trans-MK-341) is an isomer of Tranilast (HY-B0195), and an anti-allergy agent used in studies of bronchial asthma, allergic rhinitis, and atopic dermatitis .

HY-A0075

Decloxizine dihydrochloride 1 Publications Verification UCB 1402 dihydrochloride; NSC289116 dihydrochloride	Histamine Receptor 5-HT Receptor	Inflammation/Immunology
Decloxizine (UCB-1402; NSC289116) dihydrochloride is an orally active bronchodilator that can penetrate the blood-brain barrier. Decloxizine dihydrochloride is a piperazine-type H₁ histamine receptor antagonist. Decloxizine dihydrochloride selectively blocks H1 histamine receptors, inhibiting histamine-induced capillary dilation, edema, and itching. Decloxizine dihydrochloride has some 5-HT₂ receptor antagonistic activity. Decloxizine dihydrochloride can be used in studies of urticaria, allergic rhinitis, and bronchial asthma .

HY-17457

Levalbuterol hemitartrate Levosalbutamol hemitartrate	Adrenergic Receptor PI3K	Inflammation/Immunology
Levalbuterol (Levosalbutamol) hemitartrate is a β₂-adrenergic receptor agonist and PI3K inhibitor. Levalbuterol hemitartrate inhibits PI3K activity, reduces NF-κB and Rb protein expression, activates the cAMP/PKA pathway, and stimulates cAMP release. Levalbuterol hemitartrate relaxes airway smooth muscle, reduces intracellular calcium levels, and inhibits spasmogen-induced contractions. Levalbuterol hemitartrate can be used for the research of moderate-to-severe asthma .

HY-176800

LMD-902	CCR	Neurological Disease Inflammation/Immunology
LMD-902, a LMD-009 (HY-121885) analog, is a CCR8 agonist with an EC₅₀ of 15  nM. LMD-902 has a superior binging capacity depending on key residues such as PheVI:16. LMD-902 can be used for inflammation diseases like bronchial asthma and central nervous system diseases like multiple sclerosis research .

HY-119995

Chloropyramine	Apoptosis Histamine Receptor	Cardiovascular Disease Cancer
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma .

HY-108353A

Isoprenaline hemisulfate Maximum Cited Publications 87 Publications Verification	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0320AR

Cromolyn disodium (Standard) Cromoglycate disodium (Standard); Cromoglicic acid disodium (Standard); FPL-670 (Standard)	Reference Standards GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn disodium (Standard) (Cromoglycate disodium (Standard)) is the analytical standard of Cromolyn disodium (HY-B0320A). This product is intended for research and analytical applications. Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B0436R

Salbutamol hemisulfate (Standard) Albuterol hemisulfate (Standard); AH-3365 hemisulfate (Standard)	Reference Standards Adrenergic Receptor ERK	Inflammation/Immunology Cancer
Salbutamol (Albuterol) hemisulfate (Standard) is the analytical standard of Salbutamol hemisulfate (HY-B0436). This product is intended for research and analytical applications. Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.

HY-B1037S3

Salbutamol-d9 acetate Albuterol-d9 acetate; AH-3365-d9 acetate	Isotope-Labeled Compounds ERK Adrenergic Receptor	Inflammation/Immunology Cancer
Salbutamol-d₉ (Albuterol-d₉) acetate is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-170397

ADORA2A/PDE4D-IN-1	Phosphodiesterase (PDE) Adenosine Receptor	Inflammation/Immunology
ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor for adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). ADORA2A/PDE4D-IN-1 can be used in research of bronchial asthma .

HY-101235

ICI 185282	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
ICI 185282 is a potent, selective, orally active thromboxane A2 (TXA₂) receptor antagonist. ICI 185282 causes dose-dependent inhibition of U-46619 (HY-108566)-induced platelet aggregation ex-vivo in guinea-pig. ICI 185,282 inhibits bronchospasm induced by U-46619, PGD₂ (HY-101988), PGF_2α (HY-12956), arachidonic acid (HY-109590), LTD₄ and PAF (HY-108635) in vivo. ICI 185282 can be used for bronchial asthma research .

HY-W173257

Theophylline EP impurity C 6-Amino-5-1,3-dimethyl-5-(formamido)uracil	Others
Theophylline EP impurity C is an alkaloid with anti-bronchial smooth muscle spasm activity. Theophylline EP impurity C can be used to assess the purity and quality of compounds. Theophylline EP impurity C has potential clinical value in the suppression of asthma and chronic obstructive pulmonary disease.

HY-B1619R

Cromolyn (Standard) Cromoglycate (Standard); Cromoglicic acid (Standard); FPL-670 free acid (Standard)	GSK-3 NF-κB Amyloid-β Reference Standards	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Standard) is the analytical standard of Cromolyn. This product is intended for research and analytical applications. Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B0468R

Isoprenaline hydrochloride (Standard) Isoproterenol hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-17360S

Tiotropium-d3 bromide BA679 BR-d₃	Isotope-Labeled Compounds mAChR	Neurological Disease
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-B0154R

Fluticasone propionate (Standard)	Reference Standards Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-17582

Decloxizine 1 Publications Verification UCB-1402; NSC289116	Histamine Receptor 5-HT Receptor	Inflammation/Immunology
Decloxizine (UCB-1402; NSC289116) is an orally active bronchodilator that can penetrate the blood-brain barrier. Decloxizine is a piperazine-type H₁ histamine receptor antagonist. Decloxizine selectively blocks H1 histamine receptors, inhibiting histamine-induced capillary dilation, edema, and itching. Decloxizine has some 5-HT₂ receptor antagonistic activity. Decloxizine can be used in studies of urticaria, allergic rhinitis, and bronchial asthma .

HY-A0083B

Methacholine bromide Acetyl-β-methylcholine bromide	mAChR	Cardiovascular Disease
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

Cat. No.	Product Name

HY-L223

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

861 compounds

Antitussive and antiasthmatic method is a type of treatment strategy in traditional Chinese medicine, mainly used to alleviate symptoms such as coughing and asthma. These symptoms may be caused by various factors, such as: Bronchial asthma, chronic obstructive pulmonary disease, asthmatic bronchitis, cough-induced asthma, and others. Based on existing research in traditional Chinese medicine, many types of Chinese medicinal herbs showed antitussive and antiasthmatic effects. For example: Ardisiae Japonicae Herba, Ginkgo Semen, Amygdalus Communis Vas, Farfarae Flos, Viticis Cannabifoliae Fructus, Eriobotryae Folium etc. Therefore, the active ingredients derived from these traditional Chinese medicine have high medicinal value and have the potential to be developed into drugs for related diseases.

MCE can provide 861 active ingredients that can be obtained from traditional Chinese medicine with antitussive and antiasthmatic functions, which can be applied to drug development and research on disease mechanisms.

Cat. No.	Product Name	Target	Research Area

HY-120521

Urodilatin	Natriuretic Peptide Receptor (NPR)	Neurological Disease
Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991278

ABM-125	Interleukin Related	Inflammation/Immunology
ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 87 Publications Verification Isoproterenol hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-108353

Isoprenaline Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Glaucium flavum Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

HY-108353A

Isoprenaline hemisulfate Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0468R

Isoprenaline hydrochloride (Standard) Isoproterenol hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0154R

Fluticasone propionate (Standard)	Structural Classification Steroids Source Classification	Reference Standards Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload
Fluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

Cat. No.	Product Name	Chemical Structure

HY-17360S1

Tiotropium-d6 bromide

Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-B1037S

Salbutamol-d3

Salbutamol-d₃ (Albuterol-d₃) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-B1037S2

Salbutamol-d9

Salbutamol-d₉ (Albuterol-d₉) is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-B1037S3

Salbutamol-d9 acetate

Salbutamol-d₉ (Albuterol-d₉) acetate is the deuterium labeled Salbutamol (HY-B1037). Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease .

HY-17360S

Tiotropium-d3 bromide

Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

HY-14300AS

Vilanterol-d4 trifenatate

Vilanterol-d₄ (trifenatate) is deuterium labeled Vilanterol (trifenatate).Vilanterol (GW642444) acetate is a long-acting β₂ adrenergic receptor agonist. Vilanterol acetate has pEC₅₀ values for β₂-AR, β₁-AR, and β₃-AR of 9.4, 6.4, and 6.1, respectively. Vilanterol acetate selectively activates airway β₂ adrenergic receptors, increases cAMP and thus relaxes bronchial smooth muscle. Vilanterol acetate can be used in asthma research.

HY-131106S

Clorprenaline-d7
Clorprenaline-d₇ is a deuterium labeled Clorprenaline. Clorprenaline is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-W753523

Clorprenaline-d7 hydrochloride
Clorprenaline-d₇ hydrochloride is the deuterium labeled Clorprenaline hydrochloride (HY-B1347). Clorprenaline hydrochloride is a β2-adrenergic receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research .

HY-B0468S

Isoprenaline-d7 hydrochloride
Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1619S

Cromolyn-d5

Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B1810S

Tulobuterol-d9 hydrochloride
Tulobuterol-d₉ (hydrochloride) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

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