Chloropyramine
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.
For research use only. We do not sell to patients.
- CAS No.: 59-32-5
- Formula: C16H20ClN3
- Molecular Weight:289.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H1 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>60 μM
Compound: 1
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
| MDA-MB-157 | IC50 |
43.06 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-231 | IC50 |
49.73 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
| MDA-MB-453 | IC50 |
>60 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer cell lines
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Concentration:25 or 50 μM
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Incubation Time:24 h
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Result:Increased SASH1 expression in breast cancer cell lines.
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Cell Line:T47D, MDA-MB-231 and BT-54 cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Induced apoptosis in breast cancer cell lines.
Chemical Information
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CAS No. 59-32-5
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Molecular Weight 289.80
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Formula C16H20ClN3
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SMILES
CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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