Chloropyramine
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Chloropyramine hydrochloride) usually boasts enhanced water solubility and stability.
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- CAS. Nr.: 59-32-5
- Formel: C16H20ClN3
- Molecular Weight:289.80
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of Chloropyramine
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
H1 Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>60 μM
Compound: 1
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-157 | IC50 |
43.06 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-231 | IC50 |
49.73 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-453 | IC50 |
>60 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
In Vitro
Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer cell lines
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Concentration:25 or 50 μM
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Incubation Time:24 h
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Result:Increased SASH1 expression in breast cancer cell lines.
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Cell Line:T47D, MDA-MB-231 and BT-54 cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Induced apoptosis in breast cancer cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal
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Result:Reduced histamine-induced hypothermia.
Chemical Information
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CAS. Nr. 59-32-5
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Molecular Weight 289.80
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Formel C16H20ClN3
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SMILES
CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chloropyramine Related Classifications
HY-119995 Related Classifications
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