Ibuterol hydrochloride
Ibuterol (KWD 2058) hydrochloride, a diester of Terbutaline (HY-B0802A), is an orally active, selective and effective β-stimulating agent with lipophilic activities. Ibuterol hydrochloride is also an orally active ocular hypotensive agent. Ibuterol hydrochloride relieves bronchial obstruction in asthma without causing circulatory effects. Ibuterol hydrochloride is proming for rasearch of intraocular hypertension, asthma and bronchitis.
For research use only. We do not sell to patients.
- CAS No.: 57576-17-7
- Formula: C20H32ClNO5
- Molecular Weight:401.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 57576-17-7
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Molecular Weight 401.92
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Formula C20H32ClNO5
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SMILES
O=C(C(C)C)OC1=CC(C(CNC(C)(C)C)O)=CC(OC(C(C)C)=O)=C1.Cl
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Synonyms
KWD 2058 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
[1]. Arner B, et al. Comparison between ibuterol hydrochloride and terbutaline in asthma. Br Med J. 1976 Jan 10;1(6001):72-4. [Content Brief]
[2]. Phipps TL, et al. Effects of ibuterol, a beta-2 adrenergic prodrug, on intraocular pressure. J Ocul Pharmacol. 1986 Summer;2(3):225-37. [Content Brief]
[3]. Larsson S, et al. Comparison of intravenous ibuterol (KWD 2058), a new bronchodilator, and terbutaline. Eur J Clin Pharmacol. 1977 Jul 19;11(6):429-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ibuterol hydrochloride Related Classifications
HY-163994 Related Classifications
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