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Cat. No.: HY-105594

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Nivimedone

(Synonyms: BRL 10833 free base)

Nivimedone (BRL 10833 free base) is an orally active antiallergic agent. Nivimedone inhibits IgE-mediated passive cutaneous anaphylaxis in rats. Nivimedone suppresses antigen-induced histamine release from lung tissues passively sensitized with atopic serum. Nivimedone can be used in research related to bronchial asthma.

For research use only. We do not sell to patients.

CAS No.: 49561-92-4
Formula: C₁₁H₉NO₄
Molecular Weight:219.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nivimedone Chemical Structure

CAS No.: 49561-92-4

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Biological Activity
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- In Vivo
Chemical Information
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Biological Activity

Description

All Histamine Receptor Isoforms :

In Vitro

Nivimedone inhibits IgE-mediated, antigen-induced histamine release from passively sensitized human lung tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nivimedone inhibits IgE-mediated passive cutaneous anaphylaxis in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 49561-92-4
Molecular Weight 219.19
Formula C₁₁H₉NO₄
SMILES

O=C1C([N+]([O-])=O)C(C2=C1C=C(C)C(C)=C2)=O
Synonyms

BRL 10833 free base
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lumb EM, et al. The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils. Br J Clin Pharmacol. 1979;8(1):65-74. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Nivimedone

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Nivimedone Related Classifications

HY-105594 Related Classifications