2. Immunology/Inflammation
  3. Interleukin Related
  4. ABM-125

ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations.

For research use only. We do not sell to patients.

ABM-125

ABM-125 Chemical Structure

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ABM-125 Related Antibodies

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Description

ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

IL-25
In Vitro

ABM-125 potently neutralizes mammalian cell-expressed human and mouse IL-25 with a sub-micromolar IC50[1].
ABM-125 modulates RV-induced inflammatory cytokine expression and enhances anti-viral interferon production in fully differentiated asthmatic BECs from mild, moderate, and severe eosinophilic asthmatics[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABM-125 Related Antibodies
Gene ID

64806  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.64 kDa

SMILES

[*][B][M125]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ABM-125 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABM-125ABM125ABM 125Interleukin RelatedILanti-viral interferonmouseallergic airways diseasehumaninflammatory cytokinesrhinovirusasthmatic bronchial epithelial cellsmouse modeltype-2 immuneIL-25Inhibitorinhibitorinhibit

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