IL25 - interleukin 25 Gene

Also Known as IL17E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64806

About IL25

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,372,809-23,376,403 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

IL25 Products (2)

mRNA Protein Name
NM_022789.4 NP_073626.1 interleukin-25 isoform 1 precursor
NM_172314.2 NP_758525.1 interleukin-25 isoform 2 precursor

IL25 Protein Structure

IL17

IL17: Interleukin-17 (85 - 172)

  • 0
  • 100
  • 177 a.a.
Protein Preferred Names Protein Names

interleukin-25

  • interleukin-17E

Recombinant IL25 Proteins

Cat. No. Product Name Accession Purity
HY-P72555 IL-25/IL-17E Protein, Human (HEK293, His) Q9H293-1 (Y33-G177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74813 IL-25/IL-17E Protein, Human (HEK293, Fc) Q9H293-1 (Y33-G177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700116AF Animal-Free IL-25/IL-17E Protein, Human (His) Q9H293-1 (Y33-G177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701012 IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi) Q9H293-1 (Y33-G177) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Psoriasis 11

  • PSORS11

  • Psoriasis Susceptibility 11

  • Psoriasis

  • Psoriasis Vulgaris

  • Psoriasis 11, Susceptibility To

  • Pv
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991266 SM-17 Inhibitor 96.98% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06744 IL25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08889 MYDGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17706 Mydgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22207 Il25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28729 Il25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990216 Anti-Mouse IL-25 Antibody (2C3) Inhibitor 95.00% Unkown
HY-P991103 Anti-IL-25 Antibody Inhibitor 99.60% Unkown
HY-P991278 ABM-125 Inhibitor 96.92% Unkown
HY-P992244 Anti-IL25/IL17E Antibody (ABM109.2) Inhibitor / Unkown
HY-P992486 XKH001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL25 MGD MGI:2155888
Canis familiaris IL25 VGNC VGNC:41975
Bos taurus IL25 VGNC VGNC:30149
Felis catus IL25 VGNC VGNC:80950
Macaca mulatta IL25 VGNC VGNC:84356
Rattus norvegicus IL25 RGD RGD:1561632
Others IL25 NCBI