Anti-Mouse IL-25 Antibody (2C3)
Based on 1 Customer Validation
Anti-Mouse IL-25 Antibody (2C3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-25. Anti-Mouse IL-25 Antibody (2C3) can neutralize IL-25. Anti-Mouse IL-25 Antibody (2C3) can be used for inflammation researches, such as colitis and asthma.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mouse IgG1 kappa
Mouse
IL-25
Anti-Mouse IL-25 Antibody (2C3) (500 μg/mouse, i.p., at 1 day before each OVA sensitization and 4 h before each OVA aerosolization) significantly reduces inflammation and prevents airway hyperresponsiveness in Ovalbumin (OVA)-induced allergic asthma mice models[2].
Anti-Mouse IL-25 Antibody (2C3) (500 μg, i.p., 4 or 12 h before each MCT) strongly inhibits allergy development in MCT (medium chain triglycerides)-induced allergy mice models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Oxazolone (HY-126360)-induced colitis mice models (BALB/c, female)[1]
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Dosage:500 μg/mouse
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Administration:Intraperitoneally injection, before colitis-induction
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Result:Significantly reduced weight loss, diarrhea and gross bleeding.
Completely reversed shortening of the colon.
Had less damage to the intestinal walls, less ulceration, and reduced bloody stools.
Resulted in a significant decrease in the circulating numbers of eosinophils and levels of IL-4, IL-13.
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Animal Model:Ovalbumin (OVA)-induced mice models of allergic asthma (BALB/c, 6-12 weeks)[2]
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Dosage:500 μg/dose
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Administration:Intraperitoneally injection, at 1 day before each OVA sensitization and 4 h before each OVA aerosolization
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Result:Resulted in a marked abrogation in airway hyperresponsiveness.
Significantly reduced the levels of cellular infiltration around the lung vasculature, goblet cell hyperplasia in the airways, and levels of antigen-specific serum IgE and eosinophil infiltration.
Decreased the levels of IL-5 and IL-13.
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Animal Model:MCT (medium chain triglycerides)-induced allergy mice models (BALB/c, female, 7-8 weeks)[3]
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Dosage:500 μg
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Administration:Intraperitoneally injection, 4 or 12 h before each MCT
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Result:Suppressed development of shock (hypothermia) .
Decreased MMCP1.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo IL-25 neutralization
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-25 Antibody (2C3)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Camelo A, et al. Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. J Gastroenterol. 2012 Nov;47(11):1198-211. [Content Brief]
[2]. Ballantyne SJ, et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol. 2007 Dec;120(6):1324-31. [Content Brief]
[3]. Khodoun MV, et al. Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33. J Allergy Clin Immunol. 2018 Jan;141(1):171-179.e1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-25 Antibody (2C3) Related Classifications
HY-P990216 Related Classifications
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