1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Pemirolast potassium

Pemirolast potassium (Synonyms: TWT-8152; BMY 26517)

Cat. No.: HY-B0538A Purity: 99.93%
Handling Instructions

Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

For research use only. We do not sell to patients.

Pemirolast potassium Chemical Structure

Pemirolast potassium Chemical Structure

CAS No. : 100299-08-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in Water USD 67 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 67 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 61 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 165 In-stock
Estimated Time of Arrival: December 31
500 mg USD 275 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. Target: Histamine H1 Receptor Pemirolast potassium (TWT-8152) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1]. Pemirolast potassium (TWT-8152) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, Pemirolast potassium (TWT-8152) reduces kaolin intake by inhibition of substance P release in rats [2]. Pemirolast potassium (TWT-8152) potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats [3]. Pemirolast potassium (TWT-8152) potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel [4].

Clinical Trial
Molecular Weight

266.30

Formula

C10H7KN6O

CAS No.
SMILES

O=C1C(C2=N[N-]N=N2)=CN=C3N1C=CC=C3C.[K+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (187.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7552 mL 18.7758 mL 37.5516 mL
5 mM 0.7510 mL 3.7552 mL 7.5103 mL
10 mM 0.3755 mL 1.8776 mL 3.7552 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Pemirolast potassium
Cat. No.:
HY-B0538A
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