2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. NCO-650 free base

NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma.

For research use only. We do not sell to patients.

NCO-650 free base

NCO-650 free base Chemical Structure

CAS No. : 81907-78-0

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NCO-650 free base Related Antibodies

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Description

NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma[1][2][3].

In Vitro

NCO-650 free base potently inhibits histamine release from rat peritoneal mast cells induced by antigen (IC50 = 1.9 μM), anti-IgE (IC50 = 3.6 μM), Concanavalin A (HY-P2149) (IC50 = 4.6 μM), Ionophore A23187 (HY-N6687) (IC50 = 2.9 μM), and Compound 48/80 (HY-115768) (IC50 = 6.1 μM) via dose-dependent action[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NCO-650 free base Related Antibodies
In Vivo

NCO-650 (100 mg/kg; i.d.; single dose) free base produces a 64% inhibition of Compound 48/80 (HY-115768)-induced bronchoconstriction in anesthetized male mongrel dogs, while also blocking associated vascular effects without altering histamine-induced bronchoconstriction[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel (male, 8.5-18.5 kg, anesthetized, nonimmunologically induced bronchial asthma model)[3]
Dosage: 100 mg/kg
Administration: i.d.; single dose
Result: Produced a 64% inhibition of the maximal increase in ventilation overflow induced by compound 48/80.
Significantly inhibited the decreases in perfusion pressure and systemic blood pressure caused by compound 48/80.
Had no effect on ventilation overflow, perfusion pressure, or systemic blood pressure when administered alone.
Did not inhibit the increase in ventilation overflow induced by inhalation of 0.005-0.01% histamine for 10 min.
Molecular Weight

331.45

Formula

C19H29N3O2
CAS No.
SMILES

O=C([C@H]1CC[C@@H](CC1)CNC(N)=N)OC2=CC=C(C=C2)C(C)(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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NCO-650 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCO-65081907-78-0NCO650NCO 650Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasestrypsincAMPbronchoconstrictionrat peritoneal mast cellsanti-IgEConcanavalin Ahistaminetrypsin-like enzymeallergic diseasemast cellsInhibitorinhibitorinhibit

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