81907-78-0
81907-78-0
Chemical Structure
NCO-650 free base
- CAS No.: 81907-78-0
- Formula:C19H29N3O2
- Molecular Weight:331.45
InChIKey: HXLJIJAWKVNQNT-HDJSIYSDSA-N
SMILES: O=C([C@H]1CC[C@@H](CC1)CNC(N)=N)OC2=CC=C(C=C2)C(C)(C)C
Biological Activity: NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma[1][2][3].
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NCO-650 free base | NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma. | |||||||||||||||||||||
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References
- [1]. Takei M, et al. Inhibitory effect of anti-allergic agent NCO-650 on histamine release induced by various secretagogues. Agents Actions. 1988;25(1-2):17-21. [Content Brief]
- [2]. Takei M, et al. Inhibition of cAMP increase by an anti-allergic agent, NCO-650, during histamine release. Int Arch Allergy Appl Immunol. 1989;88(4):377-380. [Content Brief]
- [3]. Misawa M, et al. Effects of mast cell stabilizers on a new bronchial asthma model using compound 48/80 in dogs. Jpn J Pharmacol. 1987;44(2):197-205. [Content Brief]
