58 Results for "

protein glycosylation

" in MedChemExpress (MCE) Product Catalog:
Products (58)

58 Results for "protein glycosylation" in MCE Product Catalog:

180
180 Publications Verification
Cat. No.: HY-A0098
CAS No.: 11089-65-9
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .
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10
10 Cited Publications
Cat. No.: HY-P7387
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MIF; L-Dopachrome Isomerase; Prev. GLIF; glycosylation-Inhibiting Factor; Phenylpyruvate Tautomerase; MMIF; GIF; Epididymis Secretory Sperm Binding protein; L-Dopachrome Tautomerase; Macrophage Migration Inhibitory Factor; Macrophage Migration Inhibitory Factor (glycosylation-Inhibiting Factor)
Species:  
Human
Source:  
E. coli
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3
3 Cited Publications
Cat. No.: HY-W013707
CAS No.: 81012-87-5
Synonyms: Cytidine triphosphate disodium dihydrate; 5'-CTP disodium dihydrate
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Cytidine-5'-triphosphate disodium dihydrate (5'-CTP disodium dihydrate) is a molecule of high energy, and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation .
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3
3 Cited Publications
Cat. No.: HY-P7388
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MIF; L-Dopachrome Isomerase; Prev. GLIF; glycosylation-Inhibiting Factor; Phenylpyruvate Tautomerase; MMIF; GIF; Epididymis Secretory Sperm Binding protein; L-Dopachrome Tautomerase; Macrophage Migration Inhibitory Factor; Macrophage Migration Inhibitory
Species:  
Mouse
Source:  
E. coli
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2
2 Cited Publications
Cat. No.: HY-P7467
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGER; Receptor For Advanced glycosylation End-Products Deletion Exon3-10 Variant; Advanced glycosylation End-Product Specific Receptor; Receptor For Advanced glycosylation End-Products Deletion Exon2-6 Variant; RAGE; Advanced glycosylation End Product-Spe
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-N1347
CAS No.: 490-31-3
Synonyms: 3,3',4',5',7-Pentahydroxyflavone
Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .
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1
1 Cited Publications
Cat. No.: HY-129099A
CAS No.: 15917-65-4
Purity:  99.93%
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
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1
1 Cited Publications
Cat. No.: HY-P3443
Synonyms: PNA
Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions .
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1
1 Cited Publications
Cat. No.: HY-138802
CAS No.: 1306638-12-9
Purity:  99.86%
ML089 is an orally active inhibitor of phosphomannose isomerase (PMI) and PHOSPHO1, with an IC50 value of 1.3 μM against human PMI and an IC50 value of 0.8 μM against PHOSPHO1. ML089 blocks the catabolism of mannose-6-phosphate, directs mannose-6-phosphate to participate in protein glycosylation, increases mannose incorporation into cellular proteins, and reduces tritiated water production from mannose-6-phosphate. ML089 inhibits PMI in living cells. ML089 can be used in research related to congenital disorder of glycosylation type Ia (CDG-Ia) .
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1
1 Cited Publications
Cat. No.: HY-129099
CAS No.: 31750-48-8
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
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1
1 Cited Publications
Cat. No.: HY-KE7057

O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.

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Cat. No.: HY-113357
CAS No.: 588-30-7
Purity:  99.84%
m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats .
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Cat. No.: HY-NP0196
Synonyms: Mouse IgG
Mouse Immunoglobulin G (Mouse IgG) is the most abundant glycoprotein in mouse serum, which bridges innate and adaptive immune responses. A conserved asparagine-297 residue on each heavy chain contains an N-linked glycosylation site. Mouse Immunoglobulin G shares many glycosylation features with human IgG, but contains N-Glycolylneuraminic acid (HY-128965) instead of N-acetylneuraminic acid (HY-I0400). Mouse Immunoglobulin G is widely used as a negative isotype control, immunoassay coating protein and research standard in the life sciences .
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Cat. No.: HY-137042
CAS No.: 1223357-57-0
Purity:  98.15%
Synonyms: Alkyne-Cy5
Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC) . Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No.: HY-164390
CAS No.: 64364-50-7
Synonyms: Neu5Acα2-6Galβ1-4GlcNAc
Target:  

Endogenous Metabolite

Research Areas:  

Infection Cancer

6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .
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Cat. No.: HY-W674039
CAS No.: 20847-05-6
6-Azido-6-deoxy-D-glucose, 95% is used for visualizing protein-specific glycosylation in living cells.
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Cat. No.: HY-16304
CAS No.: 27251-84-9
Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders .
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Cat. No.: HY-E70290
Synonyms: GALNT1
Research Areas:  

Cancer

N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
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Cat. No.: HY-W040294
CAS No.: 97-30-3
Synonyms: Methyl α-D-glucopyranoside
Methyl α-D-glucoside (Methyl α-D-glucopyranoside) can be used for protein glycosylation modification. Methyl α-D-glucoside is a kind of biological materials or organic compounds that are widely used in life science research .
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Cat. No.: HY-W010076
CAS No.: 2150-47-2
Target:  

Fungal

Research Areas:  

Infection

Methyl 2,4-dihydroxybenzoate is an antifungal agent and plant defense activator. Methyl 2,4-dihydroxybenzoate disrupts the fungal antioxidant system, induces oxidative stress, interferes with N-glycosylation and protein synthesis, inhibits energy metabolism, and impairs transport function. Methyl 2,4-dihydroxybenzoate exhibits potent antifungal activity against the causal agent of banana Panama disease (Fusarium oxysporum f. sp. cubense) . Methyl 2,4-dihydroxybenzoate can also serve as a cosmetic raw material and is used in the synthesis of fine chemical raw materials. Methyl 2,4-dihydroxybenzoate is applicable to research related to Panama disease (Fusarium wilt) .
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