AGER Protein, Cynomolgus (HEK293, His)

AGER protein serves as a cell surface pattern recognition receptor with a diverse ligand repertoire, encompassing advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids, and glycosaminoglycans. Notably, advanced glycosylation end products, which accumulate in vascular tissue during aging and diabetes, act as key ligands triggering inflammatory responses via RAGE. Upon ligand binding, AGER utilizes TIRAP and MYD88 as adapters to transduce signals, leading to the induction of inflammatory cytokines such as IL6, IL8, and TNFalpha through NF-kappa-B activation. AGER's interaction with S100A12 and S100B induces cellular activation, generating pro-inflammatory mediators and contributing to diverse processes, including myocardial infarction-induced apoptosis, amyloid-beta peptide translocation, endothelial albumin transcytosis, and extracellular vesicle-mediated delivery of HMGB1 to hepatocytes. Moreover, AGER participates in the uptake of extracellular hypomethylated DNA and can induce nuclear factor NF-kappa-B activation in response to advanced glycosylation end products. The multifaceted roles of AGER highlight its involvement in various pathological conditions, such as diabetes, vascular complications, neurodegenerative disorders, and cancer.