1. Anti-infection
    Metabolic Enzyme/Protease
  2. Fungal
    HIV Integrase
    Bacterial
  3. Robinetin

Robinetin (Synonyms: 3,3',4',5',7-Pentahydroxyflavone)

Cat. No.: HY-N1347 Purity: >97.0%
Handling Instructions

Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation.

For research use only. We do not sell to patients.

Robinetin Chemical Structure

Robinetin Chemical Structure

CAS No. : 490-31-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 325 In-stock
Estimated Time of Arrival: December 31
5 mg USD 295 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation[1][2][3][4][5].

In Vitro

Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner[1].
Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus[2].
Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency[3].
Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.24

Formula

C₁₅H₁₀O₇

CAS No.

490-31-3

SMILES

O=C1C(O)=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (397.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3086 mL 16.5431 mL 33.0863 mL
5 mM 0.6617 mL 3.3086 mL 6.6173 mL
10 mM 0.3309 mL 1.6543 mL 3.3086 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (9.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (9.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Robinetin3,3',4',5',7-PentahydroxyflavoneFungalHIV IntegraseBacterialflavonoidantifungalantiviralantibacterialantimutagenesisantioxidantlipidperoxidationproteinglycosylationInhibitorinhibitorinhibit

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Robinetin
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