Cat. No.: HY-N0849

Dictamine

(Synonyms: Dictamnine; Dectamine)

Customer Review

Based on 1 Customer Validation

Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities.

For research use only. We do not sell to patients.

Purity: 99.16%
CAS No.: 484-29-7
Formula: C₁₂H₉NO₂
Molecular Weight:199.21

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Dictamine Chemical Structure

CAS No.: 484-29-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-27	IC₅₀	19.7 μg/mL Compound: Dict	Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 34463097]
HepG2	IC₅₀	55.2 μM Compound: 13	Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
Neutrophil	IC₅₀	>50 μM Compound: 17	Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release	[PMID: 18211005]
Neutrophil	IC₅₀	>50 μM Compound: 17	Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation	[PMID: 18211005]
SCC-9	IC₅₀	27.8 μg/mL Compound: Dict	Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 34463097]

In Vitro

Dictamine shows antimicrobial activity against Saccharomyces cerevisiae (MIC: 64 μg/mL)^[1].
Dictamine (2 μg/mL, 24 h) reduces ROS and mitochondrial ROS, and reduces IL-1β, TNF-α expression in HaCaT inflammation model^[2].
Dictamine (0-100 μM, 12 h) inhibits cell proliferation, migration and invasion, and induces apoptosis in HCT116 cells, by downregulating HIF-1α and Slug. I^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

HCT116 cells
Concentration:

0-100 μM
Incubation Time:

12 h
Result:

Inhibited HIF-1α (synthesis but not degradation) and Slug protein accumulation under hypoxia.

In Vivo

Dictamine (2 μg/mL, 200 μL, applied once daily, for 14 days) reduces skin inflammation and skin swellingin Oxazolone (HY-126360)-induced atopic dermatitis mice model^[2].
Dictamine (50 and 100 mg/kg, p.o., three times a week) inhibits tumor growth in a HCT116 xenograft tumor model^[3].
Dictamine (1 and 5 mg/kg, 200 μL, applied to the skin) ameliorates chronic itch in 2,4-dinitrofluorobenzene-induced atopic dermatitis mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HCT116 xenograft tumor model^[3]
Dosage:

50 and 100 mg/kg
Administration:

p.o., three times a week
Result:

Inhibited tumor growth.
Reduced HIF-1α and Slug protein level in the tumor tissue.

Chemical Information

CAS No. 484-29-7
Appearance Solid
Molecular Weight 199.21
Formula C₁₂H₉NO₂
Color White to yellow
SMILES

COC1=C2C(OC=C2)=NC3=CC=CC=C13
Synonyms

Dictamnine; Dectamine
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (250.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0198 mL

25.0991 mL

50.1983 mL

5 mM

1.0040 mL

5.0198 mL

10.0397 mL

10 mM

0.5020 mL

2.5099 mL

5.0198 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (12.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (12.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (12.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41. [Content Brief]

[2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900. [Content Brief]

[3]. Lin CY, et al. Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model. J Control Release. 2021 Jan 10;329:731-742. [Content Brief]

[4]. Wang JY, et al. Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways. Chem Biol Interact. 2018 Dec 25;296:134-144. [Content Brief]

[5]. Yang N, et al. Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. Biochem Pharmacol. 2023 Feb;208:115368. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.0198 mL	25.0991 mL	50.1983 mL	125.4957 mL
	5 mM	1.0040 mL	5.0198 mL	10.0397 mL	25.0991 mL
	10 mM	0.5020 mL	2.5099 mL	5.0198 mL	12.5496 mL
	15 mM	0.3347 mL	1.6733 mL	3.3466 mL	8.3664 mL
	20 mM	0.2510 mL	1.2550 mL	2.5099 mL	6.2748 mL
	25 mM	0.2008 mL	1.0040 mL	2.0079 mL	5.0198 mL
	30 mM	0.1673 mL	0.8366 mL	1.6733 mL	4.1832 mL
	40 mM	0.1255 mL	0.6275 mL	1.2550 mL	3.1374 mL
	50 mM	0.1004 mL	0.5020 mL	1.0040 mL	2.5099 mL
	60 mM	0.0837 mL	0.4183 mL	0.8366 mL	2.0916 mL
	80 mM	0.0627 mL	0.3137 mL	0.6275 mL	1.5687 mL
	100 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2550 mL

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Dictamine

Bioactive Compound Library Max

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Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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Anti-Cancer Compound Library

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Pyroptosis Compound Library

Traditional Chinese Medicine Active Compound Library

Alkaloids Library

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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

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Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dictamine Related Classifications

HY-N0849 Related Classifications