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Results for "

steroidal estrogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Estrogen Receptor/ERR (48) 17β-HSD (1) Androgen Receptor (7) Apoptosis (6) Autophagy (5) Bacterial (2) Biochemical Assay Reagents (1) Calmodulin (1) Caspase (1) CDK (1) COX (4) Cytochrome P450 (9) Drug Intermediate (5) Drug Metabolite (4) Endogenous Metabolite (17) Environmental Pollutants (3) Glucocorticoid Receptor (2) GnRH Receptor (1) Insecticide (3) Isotope-Labeled Compounds (22) Mitochondrial Metabolism (1) Necroptosis (3) Nucleoside Antimetabolite/Analog (1) Progesterone Receptor (9) Reference Standards (11) Steroid Sulfatase (9)
By Research Areas:	Cancer (43) Cardiovascular Disease (6) Endocrinology (36) Infection (6) Inflammation/Immunology (1) Metabolic Disease (12) Neurological Disease (10)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Estrogen Receptor/ERR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14650

DHEA 45+ Cited Publications Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Environmental Pollutants Endogenous Metabolite Androgen Receptor	Cardiovascular Disease Endocrinology Cancer
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-B0141

Estradiol Maximum Cited Publications 122 Publications Verification β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-14248

Letrozole 15+ Cited Publications CGS 20267	Cytochrome P450 Autophagy	Cancer
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC₅₀ of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-B0216

Ethinylestradiol 5 Publications Verification Ethynyl estradiol; 17α-Ethynylestradiol	Environmental Pollutants Endogenous Metabolite Estrogen Receptor/ERR	Endocrinology Cancer
Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers .

HY-109176

Giredestrant 5 Publications Verification GDC-9545; RG6171	Estrogen Receptor/ERR	Cancer
Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity .

HY-113293B

Estrone sulfate sodium 3 Publications Verification	Endogenous Metabolite Estrogen Receptor/ERR	Metabolic Disease Cancer
Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research .

HY-B0672

Estradiol valerate β-Estradiol 17-valerate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-12452

DPN 15+ Cited Publications Diarylpropionitrile	Estrogen Receptor/ERR Apoptosis Autophagy	Neurological Disease
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC₅₀ of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases .

HY-118861A

Enclomiphene citrate 1 Publications Verification (E)-Clomiphene citrate; trans-Clomiphene citrate; Enclomifene citrate	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .

HY-B0141S2

Estradiol-d5 β-Estradiol-d₅; 17β-Estradiol-d₅; 17β-Oestradiol-d₅	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-128793

trans-Stilbene (E)-Stilbene	Drug Intermediate	Others
trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .

HY-118861

Enclomiphene 5 Publications Verification (E)-Clomiphene; trans-Clomiphene; Enclomifene	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .

HY-B0141S1

Estradiol-d4 2 Publications Verification β-Estradiol-d₄; 17β-Estradiol-d₄; 17β-Oestradiol-d₄	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-133017

Amcenestrant 3 Publications Verification SAR439859	Estrogen Receptor/ERR	Cancer
SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC₅₀ of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER ⁺ breast cancer.

HY-B0742

Hydroxyprogesterone caproate 5+ Cited Publications 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate	Progesterone Receptor	Endocrinology
Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

HY-B0487

Ethisterone Pregneninolone; 17α-Ethynyltestosterone	Estrogen Receptor/ERR	Metabolic Disease
Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring .

HY-B0141S

Estradiol-d3 β-Estradiol-d₃; 17β-Estradiol-d₃; 17β-Oestradiol-d₃	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-137243

Adenosine 3',5'-diphosphate disodium	Endogenous Metabolite Nucleoside Antimetabolite/Analog	Others
Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a K_i value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC₅₀ value of 1.5 μM in guinea pigs .

HY-123047

Tibolone	Progesterone Receptor Androgen Receptor Estrogen Receptor/ERR	Endocrinology
Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-B0891S

17α-Hydroxyprogesterone-d8 17-Hydroxyprogesterone-d₈; 17-OHP-d₈	Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone-d₈ is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B0141C

Estradiol hemihydrate Maximum Cited Publications 122 Publications Verification β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Neurological Disease Cancer
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-111484

GDC-0927 3 Publications Verification SRN-927	Estrogen Receptor/ERR	Cancer
GDC-0927 (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist .

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-137449

Rintodestrant G1T48	Estrogen Receptor/ERR CDK	Cancer
Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor .

HY-B0672R

Estradiol valerate (Standard) β-Estradiol 17-valerate (Standard)	Reference Standards Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate (Standard) is the analytical standard of Estradiol valerianate. This product is intended for research and analytical applications. Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B0141S3

Estradiol-d2 β-Estradiol-d₂; 17β-Estradiol-d₂; 17β-Oestradiol-d₂	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-110157

AC-186	Estrogen Receptor/ERR	Neurological Disease
AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC₅₀s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .

HY-B0141S5

Estradiol-13C2 β-Estradiol-¹³C₂; E2-¹³C₂; 17β-Estradiol-¹³C₂; 17β-Oestradiol-¹³C₂	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-14248R

Letrozole (Standard) CGS 20267 (Standard)	Cytochrome P450 Reference Standards Autophagy	Cancer
Letrozole (Standard) is the analytical standard of Letrozole. This product is intended for research and analytical applications. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-B1984

p,p'-DDD 1 Publications Verification 4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane	Environmental Pollutants Drug Metabolite Apoptosis Insecticide Necroptosis	Infection Neurological Disease Cancer
p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-148225

Fulvestrant 3-β-D-Glucuronide	Drug Metabolite	Cancer
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-14248S

Letrozole-d4	Isotope-Labeled Compounds Cytochrome P450 Autophagy	Cancer
Letrozole-d₄ (CGS 20267-d₄) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC₅₀ of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-113031

16a-Hydroxydehydroisoandrosterone 16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA	Cytochrome P450	Endocrinology
16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.

HY-N2026A

Propylparaben sodium 1 Publications Verification Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium	Estrogen Receptor/ERR	Cardiovascular Disease Neurological Disease
Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, induces oxidative stress, and alters the estrous cycle, hormone levels and ovarian reserve function. Propylparaben sodium inhibits the growth of antral follicles and alters the accumulation of steroid hormones in follicle culture media. Propylparaben sodium can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].

HY-105184

YM511	Cytochrome P450	Endocrinology
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones .

HY-N6741

β-Zearalenol	Others	Infection Endocrinology
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .

HY-118861B

Enclomiphene hydrochloride (E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .

HY-B0891S1

17α-Hydroxyprogesterone-13C3 17-Hydroxyprogesterone-¹³C₃; 17-OHP-¹³C₃	Isotope-Labeled Compounds Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone- ¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-141901S1

DHEA-d5 Prasterone-d₅; Dehydroisoandrosterone-d₅; Dehydroepiandrosterone-d₅	Isotope-Labeled Compounds Endogenous Metabolite Androgen Receptor	Cardiovascular Disease Endocrinology Cancer
DHEA-d₅ (Prasterone-d₅; Dehydroisoandrosterone-d₅; Dehydroepiandrosterone-d₅) is the deuterium labeled DHEA (HY-14650). DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-B0742R

Hydroxyprogesterone caproate (Standard) 5+ Cited Publications 17α-Hydroxyprogesterone hexanoate(Standard); 17α-Hydroxyprogesterone caproate (Standard)	Reference Standards Progesterone Receptor	Others
Hydroxyprogesterone caproate (Standard) is the analytical standard of Hydroxyprogesterone caproate. This product is intended for research and analytical applications. Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

HY-P5464A

SRC-1 NR box peptide acetate	Estrogen Receptor/ERR	Endocrinology
SRC-1 NR box peptide acetate is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide acetate can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-123868

KW-2581	Steroid Sulfatase	Cancer
KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC₅₀ of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC₅₀ of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC₅₀ of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer .

HY-129433

17β-HSD1-IN-2	17β-HSD	Endocrinology
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (K_i=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders .

HY-135903

Giredestrant tartrate GDC-9545 tartrate; RG6171 tartrate	Estrogen Receptor/ERR	Cancer
Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity .

HY-B0141S4

Estradiol-13C6 β-Estradiol-¹³C₆; E2-¹³C₆; 17β-Estradiol-¹³C₆; 17β-Oestradiol-¹³C₆	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-123163

JNJ-1250132 RWJ-66826; RTI-6617-003	Progesterone Receptor Glucocorticoid Receptor Androgen Receptor Estrogen Receptor/ERR	Endocrinology Cancer
JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC₅₀ of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC₅₀=0.50 nM) and the rat androgen receptor (AR) (IC₅₀=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC₅₀ >3000 nM) .

HY-125627

CP-394531	Glucocorticoid Receptor Androgen Receptor	Neurological Disease Metabolic Disease
CP-394531 is an efficient and highly selective non-steroidal glucocorticoid receptor (GR) antagonist, with a K_i value of 0.1 nM. CP-394531 has a weak binding to androgen receptor (AR) (K_i = 130 nM), and has almost no effect on progesterone receptor (PR) and estrogen receptors (ERα, ERβ). CP-394531 completely blocks the half-maximal agonistic effect induced by Dexamethasone (HY-14648G), with a K_if of 4.1 nM. CP-394531 can be used to study various diseases such as diabetes, obesity, depression, neurodegenerative diseases, glaucoma and Cushing's disease .

HY-B1984S

p,p'-DDD-d8 4,4'-DDD-d₈; p,p'-Dichlorodiphenyl dichloroethane-d₈	Drug Metabolite Apoptosis Necroptosis Insecticide	Infection Neurological Disease Cancer
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Cytochrome P450 Mitochondrial Metabolism	Metabolic Disease Cancer
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

Cat. No.	Product Name	Type

HY-W699238

S-(-)-Aminoglutethimide D-tartrate

Biochemical Assay Reagents

S-(-)-Aminoglutethimide D-tartrate is an aromatase inhibitor with activity that blocks adrenal steroidogenesis. S-(-)-Aminoglutethimide D-tartrate can be used to inhibit steroid-related diseases. S-(-)-Aminoglutethimide D-tartrate is often used clinically to control certain types of cancer. S-(-)-Aminoglutethimide D-tartrate effectively reduces testosterone and estrogen levels through an enzyme inhibition mechanism.

Cat. No.	Product Name	Target	Research Area

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-P5464A

SRC-1 NR box peptide acetate	Estrogen Receptor/ERR	Endocrinology
SRC-1 NR box peptide acetate is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide acetate can be used to study the regulatory mechanisms of estrogen receptor ligands .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14650

DHEA 45+ Cited Publications Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Androgen Receptor
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-B0141

Estradiol Maximum Cited Publications 122 Publications Verification β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Monophenols Classification of Application Fields Sunscreen Disease markers Phenols Endocrine diseases Cosmetic Research Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-14248

Letrozole 15+ Cited Publications CGS 20267	Alkaloids Classification of Application Fields Other Alkaloids Plants Compositae Disease Research Fields Source Classification Tephrosia purpurea (L.) Pers. Cancer	Cytochrome P450 Autophagy
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC₅₀ of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-B0216

Ethinylestradiol 5 Publications Verification Ethynyl estradiol; 17α-Ethynylestradiol	Structural Classification Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Estrogen Receptor/ERR
Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers .

HY-113293B

Estrone sulfate sodium 3 Publications Verification	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite Estrogen Receptor/ERR
Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research .

HY-B0141C

Estradiol hemihydrate Maximum Cited Publications 122 Publications Verification β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate	Structural Classification Endogenous metabolite Steroids Source Classification	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-14248R

Letrozole (Standard) CGS 20267 (Standard)	Alkaloids Other Alkaloids Plants Compositae Source Classification Tephrosia purpurea (L.) Pers.	Cytochrome P450 Reference Standards Autophagy
Letrozole (Standard) is the analytical standard of Letrozole. This product is intended for research and analytical applications. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-N2026A

Propylparaben sodium 1 Publications Verification Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium	Infection Structural Classification Natural Products Classification of Application Fields Cosmetic Research Endogenous metabolite Disease Research Fields Source Classification	Estrogen Receptor/ERR
Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, induces oxidative stress, and alters the estrous cycle, hormone levels and ovarian reserve function. Propylparaben sodium inhibits the growth of antral follicles and alters the accumulation of steroid hormones in follicle culture media. Propylparaben sodium can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].

HY-N6741

β-Zearalenol	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Endocrinology Source Classification	Others
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Endogenous metabolite Steroids Source Classification	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

HY-113293BR

Estrone sulfate sodium (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite Estrogen Receptor/ERR
Estrone sulfate sodium (Standard) is the analytical standard of Estrone sulfate sodium (HY-113293B). This product is intended for research and analytical applications. Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research.

HY-N6741R

β-Zearalenol (Standard)	Microorganisms Classification of Application Fields Antibiotics Phenols Disease Research Fields Endocrinology Source Classification	Reference Standards Others
β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .

Cat. No.	Product Name	Chemical Structure

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S1

Estradiol-d4 2 Publications Verification
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0891S

17α-Hydroxyprogesterone-d8
17α-Hydroxyprogesterone-d₈ is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-14248S

Letrozole-d4
Letrozole-d₄ (CGS 20267-d₄) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC₅₀ of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer .

HY-B0891S1

17α-Hydroxyprogesterone-13C3
17α-Hydroxyprogesterone- ¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-141901S1

DHEA-d5

DHEA-d₅ (Prasterone-d₅; Dehydroisoandrosterone-d₅; Dehydroepiandrosterone-d₅) is the deuterium labeled DHEA (HY-14650). DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-B2158S

Chlorotrianisene-d9
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-123047S

Tibolone-d5
Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-W698952S

3β hydroxy Tibolone-d5
3β hydroxy Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-B0672S

Estradiol valerianate-d9
Estradiol valerianate-d₉ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B0672S1

Estradiol valerianate-d4
Estradiol valerianate-d₄ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B1662S2

(Rac)-Hexestrol-d6-1
(Rac)-Hexestrol-d₆-1 is the deuterium labeled (Rac)-Hexestrol (HY-W354544) . (Rac)-Hexestrol is the racemic form of Hexestrol (HY-B1662). Hexestrol is a synthetic non-steroidal estrogen.

HY-128793S1

trans-Stilbene-d12
trans-Stilbene-d₁₂ ((E)-Stilbene-d₁₂) is the deuterium labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .

HY-128793S3

trans-Stilbene-d2
trans-Stilbene-d₂ ((E)-Stilbene-d₂) is the deuterium labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .

HY-128793S

trans-Stilbene-13C2
trans-Stilbene- ¹³C₂ ((E)-Stilbene- ¹³C₂) is the ¹³C labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-W777582

4-tert-Octylphenol monoethoxylate-13C6

4-tert-Octylphenol monoethoxylate- ¹³C₆ is the ¹³C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .

HY-W766130

Ethisterone-13C2

Ethisterone- ¹³C₂ (Pregneninolone- ¹³C₂) is the ¹³C-labeled Ethisterone (HY-B0487). Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring.

HY-128793S2

trans-Stilbene-d10
trans-Stilbene-d₁₀ ((E)-Stilbene-d₁₀) is the deuterium labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .

HY-N6741S

β-Zearalenol-13C18
β-Zearalenol- ¹³C₁₈ is the ¹³C-labeled β-Zearalenol. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .

HY-B0742S1

Hydroxyprogesterone caproate-d8

Hydroxyprogesterone caproate-d₈ (17α-Hydroxyprogesterone hexanoate-d₈) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

Cat. No.	Product Name		Classification

HY-B0216

Ethinylestradiol 5 Publications Verification Ethynyl estradiol; 17α-Ethynylestradiol		Alkynes
Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers .

HY-123420

Dinordrin Dinordrin I		Alkynes
Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels .

Cat. No.	Product Name		Classification

HY-137243

Adenosine 3',5'-diphosphate disodium		Nucleotide Analogs Adenine Nucleotide
Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a K_i value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC₅₀ value of 1.5 μM in guinea pigs .

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