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DPN (Synonyms: Diarylpropionitrile)

Cat. No.: HY-12452 Purity: 99.66%
Handling Instructions

DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.

For research use only. We do not sell to patients.

DPN Chemical Structure

DPN Chemical Structure

CAS No. : 1428-67-7

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
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50 mg USD 240 In-stock
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100 mg USD 430 In-stock
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500 mg USD 1300 In-stock
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Description

DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].

IC50 & Target[1]

ERβ

0.85 nM (EC50)

In Vitro

DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα)[1].
DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons[2].
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner[2].
DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner[2].
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons[2].
DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DPN (10 μg; s.c.; daily, for 11 days) increases swimming and decreased immobility in the FST and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models[3]
Dosage: 10 μg/rat
Administration: Subcutaneous injections, daily, for 11 days
Result: Increased swimming and decreased immobility in the FST.
Molecular Weight

239.27

Formula

C₁₅H₁₃NO₂

CAS No.

1428-67-7

SMILES

OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (417.94 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1794 mL 20.8969 mL 41.7938 mL
5 mM 0.8359 mL 4.1794 mL 8.3588 mL
10 mM 0.4179 mL 2.0897 mL 4.1794 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.66%

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Keywords:

DPNDiarylpropionitrileEstrogen Receptor/ERRestrogenreceptorbetaAlzheimer'sdiseaseamyloidpeptideantioxidantapoptosisanti-inflammationneuroprotectionanxiety-likebehaviorsInhibitorinhibitorinhibit

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