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    Androgen Receptor
    Estrogen Receptor/ERR
  3. Tibolone

Tibolone 

Cat. No.: HY-123047
Handling Instructions

Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research.

For research use only. We do not sell to patients.

Tibolone Chemical Structure

Tibolone Chemical Structure

CAS No. : 5630-53-5

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Description

Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2].

In Vivo

Tibolone (1 mg/day; oral administration; for 12 weeks) treatment enhances the osseointegration process of intramedullary titanium implants in ovariectomized rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female albino Wistar rats bearing ovariectomy[1]
Dosage: 1 mg/day
Administration: Oral administration; daily; for 12 weeks
Result: Showed a significantly higher overall bone tissue and a higher body mass density.
Molecular Weight

312.45

Formula

C₂₁H₂₈O₂

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (320.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2005 mL 16.0026 mL 32.0051 mL
5 mM 0.6401 mL 3.2005 mL 6.4010 mL
10 mM 0.3201 mL 1.6003 mL 3.2005 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TiboloneProgesterone ReceptorAndrogen ReceptorEstrogen Receptor/ERRNR3C3progestagenicandrogenicestrogenicsteroidpostmenopausalosteoporosisInhibitorinhibitorinhibit

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Tibolone
Cat. No.:
HY-123047
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