2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Enclomiphene citrate

Enclomiphene citrate  (Synonyms: (E)-Clomiphene citrate; trans-Clomiphene citrate; Enclomifene citrate)

Cat. No.: HY-118861A Purity: 99.96%
COA Handling Instructions

Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.

For research use only. We do not sell to patients.

Enclomiphene citrate Chemical Structure

Enclomiphene citrate Chemical Structure

CAS No. : 7599-79-3

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 90 In-stock
50 mg USD 270 In-stock
100 mg USD 400 In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Enclomiphene citrate:

Enclomiphene citrate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Enclomiphene citrate

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes[1].

In Vitro

Enclomiphene citrate (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion[2].
Enclomiphene citrate (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes[3].
Enclomiphene citrate (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enclomiphene citrate Related Antibodies
In Vivo

Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21 days-old Charles River male rats[5]
Dosage: 0.25 and 0.5 mg/animal, daily for 24 days.
Administration: Subcutaneous injection
Result: Decreased LH and testosterone levels in the serum.
Animal Model: OVX (ovariectomy) rat model[6]
Dosage: 0.03, 1, and 3 mg/kg, daily for 90 days.
Administration: Oral adminstration
Result: Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
Clinical Trial
Molecular Weight

598.08

Appearance

Solid

Formula

C32H36ClNO8
CAS No.
SMILES

Cl/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(CC)CC)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (83.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6720 mL 8.3601 mL 16.7202 mL
5 mM 0.3344 mL 1.6720 mL 3.3440 mL
10 mM 0.1672 mL 0.8360 mL 1.6720 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.83 mg/mL (1.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.83 mg/mL (1.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 0.83 mg/mL (1.39 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (258 KB) HNMR (276 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
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Enclomiphene citrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Enclomiphene7599-79-3(E)-Clomiphenetrans-ClomipheneEnclomifeneEstrogen Receptor/ERRHypogonadalhypogonadismtestosterone deficiencyovarian dysfunctionhormoneenclomiphene citrateestrogen receptor modulatortestosteroneInhibitorinhibitorinhibit

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