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  3. Enclomiphene hydrochloride

Enclomiphene hydrochloride (Synonyms: (E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride)

Cat. No.: HY-118861B
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Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.

For research use only. We do not sell to patients.

Enclomiphene hydrochloride Chemical Structure

Enclomiphene hydrochloride Chemical Structure

CAS No. : 14158-65-7

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Description

Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes[1].

In Vitro

Enclomiphene hydrochloride (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion[2].
Enclomiphene hydrochloride (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes[3].
Enclomiphene hydrochloride (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21 days-old Charles River male rats[5]
Dosage: 0.25 and 0.5 mg/animal, daily for 24 days.
Administration: Subcutaneous injection
Result: Decreased LH and testosterone levels in the serum.
Animal Model: OVX (ovariectomy) rat model[6]
Dosage: 0.03, 1, and 3 mg/kg, daily for 90 days.
Administration: Oral adminstration
Result: Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
Molecular Weight

442.42

Formula

C26H29Cl2NO

CAS No.
SMILES

Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCN(CC)CC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Enclomiphene hydrochloride
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