2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. YM511

YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.

For research use only. We do not sell to patients.

YM511 Chemical Structure

YM511 Chemical Structure

CAS No. : 148869-05-0

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5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 550 In-stock
50 mg USD 880 In-stock
100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

YM511 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1].

IC50 & Target

Aromatase

 

Molecular Weight

354.20

Formula

C16H12BrN5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC(C=C1)=CC=C1CN(N2C=NN=C2)C3=CC=C(C#N)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (705.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8233 mL 14.1163 mL 28.2326 mL
5 mM 0.5647 mL 2.8233 mL 5.6465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8233 mL 14.1163 mL 28.2326 mL 70.5816 mL
5 mM 0.5647 mL 2.8233 mL 5.6465 mL 14.1163 mL
10 mM 0.2823 mL 1.4116 mL 2.8233 mL 7.0582 mL
15 mM 0.1882 mL 0.9411 mL 1.8822 mL 4.7054 mL
20 mM 0.1412 mL 0.7058 mL 1.4116 mL 3.5291 mL
25 mM 0.1129 mL 0.5647 mL 1.1293 mL 2.8233 mL
30 mM 0.0941 mL 0.4705 mL 0.9411 mL 2.3527 mL
40 mM 0.0706 mL 0.3529 mL 0.7058 mL 1.7645 mL
50 mM 0.0565 mL 0.2823 mL 0.5647 mL 1.4116 mL
60 mM 0.0471 mL 0.2353 mL 0.4705 mL 1.1764 mL
80 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8823 mL
100 mM 0.0282 mL 0.1412 mL 0.2823 mL 0.7058 mL
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YM511 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM511148869-05-0YM 511YM-511Cytochrome P450CYPsnon-steroidalaromatasesteroid hormonesestrogenInhibitorinhibitorinhibit

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