2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Lactandrate

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1.

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Lactandrate

Lactandrate Chemical Structure

CAS No. : 43000-65-3

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Lactandrate Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].
Cellular Effect
Cell Line Type Value Description References
Hs 766 IC50
> 100 μM
Compound: 104
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
MCF7 GI50
5 μM
Compound: 104
Growth inhibition of human MCF7 cells after 48 by MTT assay
Growth inhibition of human MCF7 cells after 48 by MTT assay
[PMID: 29649739]
MIA PaCa-2 IC50
> 100 μM
Compound: 104
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
PANC-1 IC50
> 100 μM
Compound: 104
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay
[PMID: 29649739]
T47D GI50
5 μM
Compound: 104
Growth inhibition of human T47D cells after 48 by MTT assay
Growth inhibition of human T47D cells after 48 by MTT assay
[PMID: 29649739]
Molecular Weight

563.60

Formula

C31H44Cl2N2O3
CAS No.
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lactandrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactandrate43000-65-3Estrogen Receptor/ERRInhibitorinhibitorinhibit

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