KW-2581 

KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC₅₀ of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC₅₀ of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC₅₀ of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer^[1][2].

460.63

C₂₅H₃₆N₂O₄S

284045-56-3

O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)C(C(N(C(C)C)C(C)C)=O)=CC[C@@]4([H])[C@]3([H])CCC2=C1)(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ishida, H., et al ., (2007). Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo. Breast cancer research and treatment, 104(2), 211-219.  [Content Brief]

  [2]. Ishida, H., et al., (2007). A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Breast cancer research and treatment, 106(2), 215-227.  [Content Brief]