KW-2581
KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer.
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- No. CAS: 284045-56-3
- Fòrmula: C25H36N2O4S
- Peso molecular:460.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
4 nM
Compound: 5, KW-2581
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Inhibition of recombinant human STS transfected in CHO cells using MUS as substrate after 30 mins by fluorescence assay
Inhibition of recombinant human STS transfected in CHO cells using MUS as substrate after 30 mins by fluorescence assay
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[PMID: 26163883] |
Chemical Information
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No. CAS 284045-56-3
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Peso molecular 460.63
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Fòrmula C25H36N2O4S
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SMILES
O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)C(C(N(C(C)C)C(C)C)=O)=CC[C@@]4([H])[C@]3([H])CCC2=C1)(N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Ishida, H., et al ., (2007). Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo. Breast cancer research and treatment, 104(2), 211-219. [Content Brief]
[2]. Ishida, H., et al., (2007). A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Breast cancer research and treatment, 106(2), 215-227. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KW-2581 Related Classifications
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