Cat. No.: HY-N2026A

Propylparaben sodium

(Synonyms: Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Propylparaben (Propyl parahydroxybenzoate) sodium is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben sodium is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury.

For research use only. We do not sell to patients.

Purity: 99.03%
CAS No.: 35285-69-9
Formula: C₁₀H₁₁NaO₃
Molecular Weight:202.18

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Propylparaben sodium Chemical Structure

CAS No.: 35285-69-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

All Sodium Channel Isoforms :

All PI3K Isoforms :

All JNK Isoforms :

All Akt Isoforms :

In Vitro

Propylparaben sodium shows weak estrogenic activity, with a potency approximately 30,000-fold less than 17β-estradiol^[1].
Propylparaben sodium disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Propylparaben (0-1% in diet; dietary; continuous; 28 days) sodium disrupts male reproductive function in immature rats, causing dose-dependent reductions in sperm parameters and serum testosterone^[1].
Propylparaben (7.5 mg/kg; p.o.; daily for 8 months) sodium significantly alters the estrous cycle, hormone levels and ovarian reserve, and accelerated ovarian aging in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Crj:Wistar rats (male, 19-21 days old, 52.5 g) fed with slightly modified AIN93G diet^[1]
Dosage:

0; 0.01; 0.1; 1% in diet
Administration:

dietary; continuous; 28 days
Result:

Reduced final body weight slightly but significantly at 1.00% dietary concentration.
Decreased cauda epididymal sperm reserves and sperm concentrations in a dose-dependent manner.
Decreased daily sperm production (DSP) and sperm production efficiency in the testes in a dose-dependent manner.
Decreased serum testosterone concentration in a dose-dependent manner, with a significant reduction to 64.6% of the control value at the 1.00% dietary concentration.

Animal Model:

Cycling wild-type female Swiss mice^[5]
Dosage:

7.5 mg/kg
Administration:

p.o.; daily for 8 months
Result:

Significantly altered the estrous cycle, hormone levels and ovarian reserve.
Accelerated ovarian aging of female mice.

Chemical Information

CAS No. 35285-69-9
Appearance Solid
Molecular Weight 202.18
Formula C₁₀H₁₁NaO₃
Color White to off-white
SMILES

O=C(OCCC)C1=CC=C(O[Na])C=C1
Synonyms

Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Ecotoxicol Environ Saf

A combined study of network-based prediction and in vitro experimental validation on the procarcinogenic mechanism of propylparaben in estrogen receptor-positive breast cancer cells. [Abstract]

2025 Dec 3:309:119504. PMID: 41344141

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Oishi S, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002;40(12):1807-1813. [Content Brief]

[2]. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82. [Content Brief]

[3]. Ji X, et al. Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life Sci. 2004;74(24):3043-3052. [Content Brief]

[4]. Yan W, et al. Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice. Ecotoxicol Environ Saf. 2022;235:113432. [Content Brief]

[5]. Gal A, et al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019;89:100-106. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Propylparaben sodium

1 Cited Publications

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Propylparaben sodium

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Membrane Transporter/Ion Channel Compound Library

PI3K/Akt/mTOR Compound Library

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Publications Citing Use of MedChemExpress (MCE) Propylparaben sodium

All Estrogen Receptor/ERR Isoforms

All Sodium Channel Isoforms

All PI3K Isoforms

All JNK Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Propylparaben sodium Related Classifications

Cat. No.: HY-N2026A