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    Immunology/Inflammation
  2. Estrogen Receptor/ERR
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  3. Chlorotrianisene

Chlorotrianisene 

Cat. No.: HY-B2158
Handling Instructions

Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood.

For research use only. We do not sell to patients.

Chlorotrianisene Chemical Structure

Chlorotrianisene Chemical Structure

CAS No. : 569-57-3

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Description

Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].

IC50 & Target

Estrogen receptor[1]
COX-1[2]

In Vitro

Comparison of intracellular estrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC50 of 28 nM and a Ki of 500 nM in MCF-7 cells[1].

In Vivo

The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [3H]estradiol (E2)[3].

Molecular Weight

380.86

Formula

C₂₃H₂₁ClO₃

CAS No.

569-57-3

SMILES

Cl/C(C1=CC=C(OC)C=C1)=C(C2=CC=C(OC)C=C2)/C3=CC=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ChlorotrianiseneEstrogen Receptor/ERRCOXCyclooxygenaseCOX-1proestrogenproantiestrogenintermediateNADPHestradiolantiestrogenicplateletaggregationInhibitorinhibitorinhibit

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