569-57-3
569-57-3
Chemical Structure
Chlorotrianisene
- CAS No.: 569-57-3
- Formula:C23H21ClO3
- Molecular Weight:380.86
IUPAC Name: 4,4',4''-(2-chloroethene-1,1,2-triyl)tris(methoxybenzene)
InChIKey: BFPSDSIWYFKGBC-UHFFFAOYSA-N
SMILES: Cl/C(C1=CC=C(OC)C=C1)=C(C2=CC=C(OC)C=C2)/C3=CC=C(OC)C=C3
Biological Activity: Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].
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Chlorotrianisene | 99.02% | Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood. | ||||||||||||||||||||
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Chlorotrianisene (Standard) | ≥98% | Chlorotrianisene (Standard) is the analytical standard of Chlorotrianisene. This product is intended for research and analytical applications. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood. | ||||||||||||||||||||
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Chlorotrianisene-d9 | Chlorotrianisene-d9 is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-W0750821,1,2,2-Tetrakis(4-methoxyphenyl)ethene -
Similarity Score 0.65
HY-115539Windorphen -
Similarity Score 0.64
HY-118861BEnclomiphene hydrochloride -
Similarity Score 0.64
HY-A0287AClomiphene hydrochloride -
Similarity Score 0.64
HY-118861Enclomiphene -
Similarity Score 0.64
HY-A0287Clomiphene -
Similarity Score 0.64
HY-B1617Zuclomiphene -
Similarity Score 0.62
HY-W1124844-(4-(2,2-Bis(4-methoxyphenyl)-1-phenylvinyl)phenyl)pyridine -
Similarity Score 0.61
HY-W456396(E)-4-(4-(2,2-Bis(4-methoxyphenyl)-1-phenylvinyl)styryl)pyridine -
Explore the MedChemAI to find more analogs
References
- [1]. Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):203-9. [Content Brief]
- [2]. Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486(7403):361-7. [Content Brief]
- [3]. Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62. [Content Brief]
