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Referencia número: HY-150543

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Steroid sulfatase-IN-3

Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC₅₀ of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC₅₀ of 1.04 µM.

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No. CAS: 2413880-53-0
Fòrmula: C₁₇H₂₁ClN₂O₄S
Peso molecular:384.88

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Steroid sulfatase-IN-3 Chemical Structure

No. CAS: 2413880-53-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC50: 25.8 nM (STS, in JEG-3 cell lysate), 150.0 nM (STS, in JEG-3 cells)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
JEG-3	IC₅₀	150 nM Compound: 1q	Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis	[PMID: 32173116]
JEG-3	IC₅₀	25.8 nM Compound: 1q	Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis	[PMID: 32173116]
T47D	IC₅₀	1.04 μM Compound: 1q	Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay	[PMID: 32173116]

Chemical Information

No. CAS 2413880-53-0
Peso molecular 384.88
Fòrmula C₁₇H₂₁ClN₂O₄S
SMILES

O=S(OC1=CC=C(C(NC2(C3)CC4CC3CC(C4)C2)=O)C=C1Cl)(N)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. El-Gamal MI, et al. A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. Bioorg Med Chem. 2020 Apr 15;28(8):115406. [Content Brief]

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Steroid sulfatase-IN-3

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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Steroid sulfatase-IN-3

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Steroid sulfatase-IN-3 Related Classifications

HY-150543 Related Classifications