Steroid sulfatase-IN-3
Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM.
For research use only. We do not sell to patients.
- CAS No.: 2413880-53-0
- Formula: C17H21ClN2O4S
- Molecular Weight:384.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 25.8 nM (STS, in JEG-3 cell lysate), 150.0 nM (STS, in JEG-3 cells)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JEG-3 | IC50 |
150 nM
Compound: 1q
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Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
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[PMID: 32173116] |
| JEG-3 | IC50 |
25.8 nM
Compound: 1q
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Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis
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[PMID: 32173116] |
| T47D | IC50 |
1.04 μM
Compound: 1q
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Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay
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[PMID: 32173116] |
Chemical Information
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CAS No. 2413880-53-0
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Molecular Weight 384.88
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Formula C17H21ClN2O4S
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SMILES
O=S(OC1=CC=C(C(NC2(C3)CC4CC3CC(C4)C2)=O)C=C1Cl)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Steroid sulfatase-IN-3 Related Classifications
HY-150543 Related Classifications
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