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Isoforms Recommended:	CK2

Results for "

ck2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Creatine Kinase (1) 11β-HSD (3) Adenosine Kinase (2) Akt (4) AMPK (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (18) ASK1 (1) ATP Synthase (1) Autophagy (10) Bcl-2 Family (1) c-Kit (1) Casein Kinase (73) Caspase (2) CDK (6) Checkpoint Kinase (Chk) (1) DAPK (1) DNA-PK (4) DYRK (2) EGFR (2) Endogenous Metabolite (2) Epigenetic Reader Domain (2) ERK (2) Fungal (1) HDAC (2) HSP (1) Isotope-Labeled Compounds (2) JNK (1) MDM-2/p53 (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NF-κB (2) p38 MAPK (1) Parasite (1) PARP (1) PI3K (6) Pim (4) Ras (2) Reactive Oxygen Species (ROS) (4) Reference Standards (9) SARS-CoV (4) SHP2 (2) Small Interfering RNA (siRNA) (3) SRPK (1) STAT (1) Survivin (1) TGF-beta/Smad (2) Topoisomerase (1) Trk Receptor (1) VEGFR (1) Wnt (1)
By Research Areas:	Cancer (75) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (9) Metabolic Disease (3) Neurological Disease (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Creatine Kinase Choline Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10108

LY294002 Maximum Cited Publications 1120 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis Autophagy	Infection Cancer
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits *CK2* with an IC₅₀ of 98 nM ^[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator .

HY-50855

Silmitasertib 55+ Cited Publications CX-4945	Casein Kinase Autophagy	Cancer
Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent *CK2* inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-14393

Emodin Maximum Cited Publications 39 Publications Verification Frangula emodin	SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects ^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-B0183

Ellagic acid 20+ Cited Publications	Casein Kinase Reactive Oxygen Species (ROS) Endogenous Metabolite SHP2	Neurological Disease Cancer
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM.

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin ^[2] .

HY-10108A

LY294002 hydrochloride Maximum Cited Publications 1120 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis	Cancer
LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC₅₀ values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits *CK2* with an IC₅₀ of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research ^[2] .

HY-14394

TBB 10+ Cited Publications NSC 231634; Casein Kinase II Inhibitor I	Casein Kinase	Cancer
TBB is a cell-permeable and ATP-competitive *CK2* inhibitor with an IC₅₀ of 0.15 μM for rat liver CK2.

HY-50855B

Silmitasertib sodium salt 55+ Cited Publications CX-4945 sodium salt	Casein Kinase Autophagy	Cancer
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent *CK2* inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-15535

DMAT 5+ Cited Publications ck2 Inhibitor; Casein kinase II Inhibitor	Casein Kinase	Cancer
DMAT is a potent and specific *CK2* inhibitor with an IC₅₀ value of 130 nM.

HY-N0559

Kirenol 1 Publications Verification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target *CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53* and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the *CK2/AKT* and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis ^[2] .

HY-139004

*SGC-CK2-1* 5 Publications Verification	Casein Kinase	Neurological Disease
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active *CK2* chemical probe with exclusive selectivity for both human CK2 isoforms, with IC₅₀s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases ^[2].

HY-132175

CK2 inhibitor 2	Casein Kinase	Cancer
CK2 inhibitor 2 is a potent, selective and orally active inhibitor of *CK2, with an IC₅₀* of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC₅₀=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity .

HY-15260

XL413 5+ Cited Publications BMS-863233	CDK	Cancer
XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-108606

PI-828 2 Publications Verification	PI3K Casein Kinase	Cancer
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, *CK2, and CK2α2* in lipid kinase assay, respectively .

HY-15260A

XL413 monohydrochloride 5+ Cited Publications BMS-863233 monohydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-115519

(E/Z)-GO289 2 Publications Verification	Casein Kinase	Cancer
(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .

HY-110052

TBCA 1 Publications Verification	Casein Kinase	Cancer
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases ^[2].

HY-15479

TTP 22 2 Publications Verification	Casein Kinase	Inflammation/Immunology Cancer
TTP 22 is a potent *CK2* inhibitor, with an IC₅₀ of 100 nM and a K_i of 40 nM.

HY-135906

CK2/ERK8-IN-1 2 Publications Verification	Casein Kinase ERK Pim DYRK Apoptosis	Cancer
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (K_i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC₅₀s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, *HIPK2* (homeodomain-interacting protein kinase 2), and DYRK1A with K_is of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy .

HY-P3815

Casein Kinase 2 Substrate Peptide 2 Publications Verification	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide is a common *CK2* substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .

HY-124833

Quinalizarin	Casein Kinase Apoptosis Fungal Reactive Oxygen Species (ROS) Caspase MDM-2/p53 PARP Bcl-2 Family Akt ERK STAT JNK p38 MAPK CDK	Infection Cancer
Quinalizarin is a protein kinase *CK2* inhibitor with a K_i of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections ^[2] .

HY-145260

*BRD4/CK2-IN-1*	Epigenetic Reader Domain Casein Kinase Apoptosis Autophagy	Cancer
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of *BRD4/CK2* (bromodomain-containing protein 4/casein kinase 2), with IC₅₀s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)

HY-156816

ON 108600	Casein Kinase DYRK	Cancer
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity .

HY-P4056A

CIGB-300 acetate P15-Tat acetate	Casein Kinase Apoptosis	Cancer
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-114653

SRPIN803	Casein Kinase SRPK	Cancer
SRPIN803 is a potent *CK2* and SRPK1 dual inhibitor, with IC₅₀s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration ^[2] .

HY-50733A

CX-5011	Casein Kinase Ras Apoptosis	Cancer
CX-5011 is a *CK2* inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death ^[2].

HY-124321

Metralindole hydrochloride	CDK	Cancer
Metralindole hydrochloride is an inhibitor of human cyclin-dependent kinase *CDK2* and human protein kinase *CK2* holoenzyme. Metralindole hydrochloride shows good potential as a non-small cell lung cancer inhibitor .

HY-149006

CK156	DAPK	Inflammation/Immunology Cancer
CK156, a chemical probe, is a highly selective death-associated protein kinase (DAPK) inhibitor with IC₅₀s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase Apoptosis	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-14393R

Emodin (Standard) Maximum Cited Publications 39 Publications Verification Frangula emodin (Standard)	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects ^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-117897

CK-2-68 1 Publications Verification	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

HY-148318

CK2α-IN-1	Casein Kinase	Cancer
CK2α-IN-1 (compound 2) is a selective *CK2α* inhibitor (IC₅₀=7.0 µM; K_i=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies .

HY-158369

CK2-IN-10	Casein Kinase	Cancer
CK2-IN-10 (31), an allosteric *CK2* inhibitor, can be used in the research of cancer .

HY-148328

CK2-IN-4	Casein Kinase	Infection Inflammation/Immunology Cancer
CK2-IN-4 (compound 5) is a protein kinase (CK2) inhibitor (IC₅₀=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis .

HY-E70625

Casein Kinase 2	Casein Kinase	Cancer
Casein Kinase 2 (CK2) is a serine/threonine protein kinase that is highly conserved among eukaryotes and has roles in many different cellular processes, such as cell survival, cell cycle regulation, cell polarity, stress responses, transcription and translation .

HY-169629

CK2 inhibitor 4	Casein Kinase	Cancer
CK2 inhibitor 4 (compound 5b) is a protein kinase CK2 inhibitor with IC₅₀ of 3.8 μM. CK2 inhibitor 4 can be used in tumor research .

HY-P3921

Casein Kinase II Substrate	Casein Kinase	Cancer
Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2 .

HY-143461

CK2 inhibitor 3	Casein Kinase	Cancer
CK2 inhibitor 3 is a potent *CK2* inhibitor with IC₅₀ value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases .

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin ^[2] .

HY-P11496

CK2 Substrate peptide	Casein Kinase	Neurological Disease
CK2 Substrate peptide (Compound RRRADDSDDDDD) is a specific *CK2* peptide substrate with K_m of 13 μM. CK2 Substrate peptide can be used for the research of neurological disease, such as Alzheimer's Disease .

HY-174350

CK2-IN-15	Casein Kinase SARS-CoV	Infection
CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase *CK2* inhibitor with an IC₅₀ value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases .

HY-103384

TMCB	Casein Kinase	Cancer
TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct K_i values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively .

HY-B0183A

Ellagic acid hydrate 20+ Cited Publications	Casein Kinase	Cancer
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive *CK2* inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-176561

IOR-160	Casein Kinase HDAC	Cancer
IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDACs. IOR-160 exhibits high selectivity for CK2 (IC₅₀ = 1.7 nM) and broad inhibitory activity against HDAC (HDAC 1, 2, 3, and 6 with IC₅₀s of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, with low activity for HDAC8). IOR-160 modulates key cellular signaling pathways by inhibiting AKT phosphorylation and increasing acetylated α-tubulin. IOR-160 inhibits tumor growth and reduces tumor burden through dual CK2/HDAC inhibition. IOR-160 is indicated for use in triple-negative breast cancer research .

HY-B0183S

Ellagic acid-13C12	Isotope-Labeled Compounds	Others
Ellagic acid- ¹³C₁₂ is ¹³ C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM ^[2].

HY-176508

KDX1381	Casein Kinase	Cancer
KDX1381 is a bivalent *CK2α* inhibitor (IC₅₀: 17 nM, K_D: 54 nM). KDX1381 has antitumor activity in mouse 786-O and A375 tumor xenograft models. KDX1381 combined with VEGFR inhibitors or DNA damaging agents enhances antitumor efficacy in mouse hepatocellular carcinoma and glioma models .

HY-121792

CK2-IN-1	Casein Kinase	Others
CK2-IN-1 is a *CK2* inhibitor, with an IC₅₀ of 150 nM .

HY-158370

CK2-IN-11	Casein Kinase	Cancer
CK2-IN-11 (32) is an allosteric *CK2* inhibitor, with high selectivity for CK2 with IC₅₀ values of 19.3 nM and 15.6 nM for the CK2α2β2 and the CK2α′2β2 isoforms, respectively .

HY-155987

CK2-IN-8	Casein Kinase	Cancer
CK2-IN-8 (compound 5c) is a *CK2* inhibitor with IC₅₀ >33 μM .

HY-12570

CK2-IN-9	Casein Kinase Wnt	Cancer
CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC₅₀ of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC₅₀ of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat .

Cat. No.	Product Name	Target	Research Area

HY-P3815

Casein Kinase 2 Substrate Peptide 2 Publications Verification	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide is a common *CK2* substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .

HY-P4056A

CIGB-300 acetate P15-Tat acetate	Casein Kinase Apoptosis	Cancer
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase Apoptosis	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-P3921

Casein Kinase II Substrate	Casein Kinase	Cancer
Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2 .

HY-P11496

CK2 Substrate peptide	Casein Kinase	Neurological Disease
CK2 Substrate peptide (Compound RRRADDSDDDDD) is a specific *CK2* peptide substrate with K_m of 13 μM. CK2 Substrate peptide can be used for the research of neurological disease, such as Alzheimer's Disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14393

Emodin Maximum Cited Publications 39 Publications Verification Frangula emodin	Classification of Application Fields Polygonaceae Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects ^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-B0183

Ellagic acid 20+ Cited Publications	Microorganisms other families Neurological Disease Classification of Application Fields Anti-aging Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Casein Kinase Reactive Oxygen Species (ROS) Endogenous Metabolite SHP2
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM.

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target *CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53* and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the *CK2/AKT* and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis ^[2] .

HY-14393R

Emodin (Standard) Maximum Cited Publications 39 Publications Verification Frangula emodin (Standard)	Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Phenols Plants Disease Research Fields Source Classification Cancer	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects ^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-B0183A

Ellagic acid hydrate 20+ Cited Publications	Classification of Application Fields Phenols Polyphenols Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Disease Research Fields Cancer Source Classification	Casein Kinase
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive *CK2* inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-B0183R

Ellagic acid (Standard)	Structural Classification Microorganisms other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Casein Kinase Reactive Oxygen Species (ROS) Endogenous Metabolite SHP2
Ellagic acid (Standard) is the analytical standard of Ellagic acid. This product is intended for research and analytical applications. Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC50 of 40 nM and a Ki of 20 nM.

HY-N0559R

Kirenol (Standard)	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

Recombinant Proteins Recommended:

Species:	Human (4) Mouse (2)
Tag:	His (3) Tag Free (2) GST (3)
Source:	Sf9 insect cells (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76825

	CK2 alpha/CSNK2A1 Protein, Mouse (sf9) Casein kinase II subunit alpha; ck II alpha; CSNK2A1; ck2A1	Mouse	Sf9 insect cells
	The CK2 α/CSNK2A1 protein is a constitutively active kinase that phosphorylates substrates and regulates cell cycle, apoptosis, transcription, and viral infection. CK2 α/CSNK2A1 also regulates the cellular clock, Wnt signaling, modulates extracellular proteins, and plays a role in viral infection. CK2 alpha/CSNK2A1 Protein, Mouse (sf9) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells, with tag free.

HY-P76296

	CK2 alpha/CSNK2A2 Protein, Human (sf9) Casein kinase II subunit alpha'; ck II alpha'; CSNK2A2; ck2A2	Human	Sf9 insect cells
	The CK2 α/CSNK2A2 protein is the catalytic subunit of the constitutively active serine/threonine protein kinase complex and can phosphorylate a variety of substrates, affecting cell cycle progression, apoptosis, transcription, and viral infection. CK2 alpha/CSNK2A2 Protein, Human (sf9) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells, with tag free.

HY-P76826

	CK2 alpha/CSNK2A1 Protein, Mouse (Active, sf9, His-GST) Casein kinase II subunit alpha; ck II alpha; CSNK2A1; ck2A1	Mouse	Sf9 insect cells
	CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CK2 alpha/CSNK2A1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76297

	CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) Casein kinase II subunit alpha'; ck II alpha'; CSNK2A2; ck2A2	Human	Sf9 insect cells
	CSNK2A2 is the catalytic subunit of the serine/threonine protein kinase complex. It regulates important processes such as cell cycle, apoptosis, and transcription, and affects viral infection. During mitosis, CSNK2A2 maintains CDK1 activity and induces cell cycle arrest. In addition, CSNK2A2 phosphorylates p53/TP53 and negatively regulates apoptosis. It widely affects cell signaling, phosphorylated caspases, the apoptotic factor NOL3, and RNA polymerase, among others. CSNK2A2 also regulates Wnt signaling and acts as a kinase for extracellular proteins. CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76263

	CSNK2A1 Protein, Human (Active, sf9, GST) 1 Publications Verification Casein kinase II subunit alpha; ck II alpha; CSNK2A1; ck2A1	Human	Sf9 insect cells
	CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CSNK2A1 Protein, Human (sf9, GST) is the recombinant human-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P702741

	CSNK2A1 Protein, Human (His) CSNK2A1; casein kinase 2 alpha 1; ckII; cka1; cka2; ck2A1; OCNDS	Human	E. coli
	The CSNK2A2 protein is a constitutively active kinase that phosphorylates substrates and controls the cell cycle, apoptosis, and transcription. CSNK2A1 Protein, Human (His) is the recombinant human-derived CSNK2A1, expressed by E. coli, with His labeled tag. The total length of CSNK2A1 Protein, Human (His) is 391 a.a..

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Cat. No.	Product Name	Chemical Structure

HY-B0183S

Ellagic acid-13C12
Ellagic acid- ¹³C₁₂ is ¹³ C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM ^[2].

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects ^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Host:	Mouse (4) Rabbit (4)
Reactivity:	Human (8) Rat (6) Mouse (6) Monkey (2) Rabbit (2)
Application:	IHC-P (6) ICC/IF (4) IHC-F (2) WB (8) FC (4) ELISA (4)
Isotype:	IgG (4) IgG1 (2) IgG2a (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84160

	CSNK2A2 Antibody (YA3857) ck2A2; CSNK2A1; FLJ43934	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	CSNK2A2 Antibody (YA3857) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CSNK2A2.

HY-P84280

	Cytokeratin 2e Antibody (YA3977) K2e; KRTE; ck-2e; KRT2A; KRT2E	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Cytokeratin 2e Antibody (YA3977) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cytokeratin 2e.

HY-P84160A

	CSNK2A2 Antibody (YA3857)(PBS only) ck2A2; CSNK2A1; FLJ43934	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	CSNK2A2 Antibody (YA3857) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CSNK2A2.

HY-P84280A

	Cytokeratin 2e Antibody (YA3977)(PBS only) K2e; KRTE; ck-2e; KRT2A; KRT2E	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Cytokeratin 2e Antibody (YA3977) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cytokeratin 2e.

HY-P83088

	CSNK2A1 Antibody (YA2833) CSNK2A1; ck2A1; Casein kinase II subunit alpha; ck II alpha	WB	Human, Mouse, Rat
	CSNK2A1 Antibody (YA2833) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CSNK2A1.

HY-P83088A

	CSNK2A1 Antibody (YA2833)(PBS only) CSNK2A1; ck2A1; Casein kinase II subunit alpha; ck II alpha	WB	Human, Mouse, Rat
	CSNK2A1 Antibody (YA2833) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CSNK2A1.

HY-P80586

	Casein Kinase 2 beta Antibody (YA563) CSNK2B; ck2N; G5A; Casein kinase II subunit beta; ck II beta; Phosvitin; Protein G5a	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Casein Kinase 2 beta Antibody (YA563) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 2 beta.

HY-P80586A

	Casein Kinase 2 beta Antibody (YA563)(PBS only) CSNK2B; ck2N; G5A; Casein kinase II subunit beta; ck II beta; Phosvitin; Protein G5a	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Casein Kinase 2 beta Antibody (YA563) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 2 beta.