CK2 alpha/CSNK2A1 Protein, Mouse (Active, sf9, His-GST)
CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CK2 alpha/CSNK2A1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CK2 alpha/CSNK2A1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Background
The catalytic subunit of CK2 alpha/CSNK2A1 protein is an integral component of a constitutively active serine/threonine-protein kinase complex, exhibiting the ability to phosphorylate numerous substrates rich in acidic residues C-terminal to the phosphorylated serine or threonine. This multifaceted kinase regulates diverse cellular processes, including cell cycle progression, apoptosis, transcription, and viral infection. Operating as a regulatory hub, CK2 alpha/CSNK2A1 integrates signals and orchestrates appropriate cellular responses, such as maintaining the spindle assembly checkpoint during mitosis and facilitating p53/TP53-mediated apoptosis. Additionally, CK2 alpha/CSNK2A1 participates in intricate signaling networks by phosphorylating various transcription factors, apoptotic regulators, and extracellular proteins. Its impact extends to the circadian clock function and viral life cycles, emphasizing its pivotal role in cellular homeostasis and response to external stimuli.
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag N-His;N-GST
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Accession
Q60737 (M1-Q391)
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Molecular Construction
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N-term
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His-GST
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Csnk2a1 (M1-Q391)
Accession # Q60737 -
C-term
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Protein Length
Full Length
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Synonyms
CSNK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase 2 Alpha 1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase II Subunit Alpha; Casein Kinase II Alpha 1 Subunit; Cka1; CK2 Catalytic Subunit Alpha; Cka2; Protein Kinase CK2;
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AA Sequence
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMSSTSMAGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANSLGIPVPAAAGAQQ
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Predicted Molecular Mass
72.9 kDa
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Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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