CSNK2A1/CK2a1
CSNK2A1 encodes CK2α, the principal catalytic subunit of casein kinase 2, which functions as a constitutively active α2β2 holoenzyme together with the regulatory β subunit. Unlike most CMGC kinases, CK2 needs no cyclin or second messenger and shows a strong preference for acidic substrates in which serine or threonine is followed by acidic residues. It phosphorylates hundreds of nuclear, cytoplasmic, and membrane proteins, tuning Wnt, PI3K-AKT, NF-κB, p53, and circadian circuits, and it supports cell survival. CK2α is frequently overexpressed in tumors, making it an established oncology target exemplified by ATP-competitive inhibitors such as silmitasertib. The recombinant subunit enables substrate discovery and inhibitor profiling.
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CSNK2A1/CK2a1 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
