1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. (E/Z)-GO289

(E/Z)-GO289 

Cat. No.: HY-115519 Purity: 99.72%
Handling Instructions

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function.

For research use only. We do not sell to patients.

(E/Z)-GO289 Chemical Structure

(E/Z)-GO289 Chemical Structure

CAS No. : 694522-87-7

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Description

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

In Vitro

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].
(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1].
(E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

419.30

Formula

C₁₇H₁₅BrN₄O₂S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Product Name:
(E/Z)-GO289
Cat. No.:
HY-115519
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