2. Apoptosis
  3. ASK1
  4. BPyO-34

BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer.

For research use only. We do not sell to patients.

BPyO-34

BPyO-34 Chemical Structure

CAS No. : 890601-68-0

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BPyO-34 Related Antibodies

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Description

BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer[1].

In Vitro

BPyO-34 inhibits recombinant human ASK1 catalytic subunit with an IC50 of 0.52 μM in an in vitro biochemical kinase assay[1].
BPyO-34 (10 μM) shows preferential inhibition of recombinant human ASK1 over recombinant human CK2, FGFR1, Tie2, JNK3, and Aurora A[1].
BPyO-34 binds to the ATP-binding pocket of human ASK1 via specific hydrogen bonding, hydrophobic, and sulfur-π interactions with key amino acid residues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPyO-34 Related Antibodies
Molecular Weight

572.65

Formula

C32H29FN2O5S
CAS No.
SMILES

O=C(C1=C(C(N(C1C2=CC(OCCC(C)C)=CC=C2)C3=NC4=C(S3)C=C(F)C=C4)=O)O)C5=CC=C6OC(CC6=C5)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BPyO-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPyO-34890601-68-0BPyO34BPyO 34ASK1Apoptosis signal-regulating kinase 1MAP3K5MAPKKK5Mitogen-activated protein kinase kinase kinase 5MEK kinase 5CK2ATP-binding pocketTie2humanFGFR1JNK3Aurora AInhibitorinhibitorinhibit

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