BPyO-34
BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer.
For research use only. We do not sell to patients.
- CAS No.: 890601-68-0
- Formula: C32H29FN2O5S
- Molecular Weight:572.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BPyO-34 inhibits recombinant human ASK1 catalytic subunit with an IC50 of 0.52 μM in an in vitro biochemical kinase assay[1].
BPyO-34 (10 μM) shows preferential inhibition of recombinant human ASK1 over recombinant human CK2, FGFR1, Tie2, JNK3, and Aurora A[1].
BPyO-34 binds to the ATP-binding pocket of human ASK1 via specific hydrogen bonding, hydrophobic, and sulfur-π interactions with key amino acid residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 890601-68-0
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Molecular Weight 572.65
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Formula C32H29FN2O5S
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SMILES
O=C(C1=C(C(N(C1C2=CC(OCCC(C)C)=CC=C2)C3=NC4=C(S3)C=C(F)C=C4)=O)O)C5=CC=C6OC(CC6=C5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BPyO-34 Related Classifications
HY-183960 Related Classifications
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