CK2 inhibitor 3
CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases.
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- CAS No.: 2979847-14-6
- Formule: C13H9BrN4O3S
- Masse moléculaire:381.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
[1]|
CK2 280 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Jurkat | DC50 |
12.8 μM
Compound: 4
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Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
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[PMID: 32283296] |
In Vitro
CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells[1]
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Concentration:0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
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Incubation Time:24 hours
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Result:Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.
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Cell Line:Jurkat cells[1]
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Concentration:5 μM and 20 μM
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Incubation Time:16 hours
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Result:Decreased the CK2-dependent phospho-site Akt Ser129 level.
Chemical Information
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CAS No. 2979847-14-6
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Masse moléculaire 381.20
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Formule C13H9BrN4O3S
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SMILES
COC1=CC(/C=C(C(NC2=NN=C(S2)Br)=O)\C#N)=CC=C1O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK2 inhibitor 3 Related Classifications
HY-143461 Related Classifications
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