CK2 inhibitor 3
CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases.
For research use only. We do not sell to patients.
- CAS No.: 2979847-14-6
- Formula: C13H9BrN4O3S
- Molecular Weight:381.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CK2 280 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | DC50 |
12.8 μM
Compound: 4
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Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
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[PMID: 32283296] |
CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells[1]
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Concentration:0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
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Incubation Time:24 hours
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Result:Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.
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Cell Line:Jurkat cells[1]
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Concentration:5 μM and 20 μM
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Incubation Time:16 hours
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Result:Decreased the CK2-dependent phospho-site Akt Ser129 level.
Chemical Information
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CAS No. 2979847-14-6
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Molecular Weight 381.20
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Formula C13H9BrN4O3S
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SMILES
COC1=CC(/C=C(C(NC2=NN=C(S2)Br)=O)\C#N)=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK2 inhibitor 3 Related Classifications
HY-143461 Related Classifications
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