2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CK2 inhibitor 3

CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases.

For research use only. We do not sell to patients.

CK2 inhibitor 3

CK2 inhibitor 3 Chemical Structure

CAS No. : 2979847-14-6

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CK2 inhibitor 3 Related Antibodies

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Description

CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases[1].

IC50 & Target[1]

CK2

280 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
Jurkat DC50
12.8 μM
Compound: 4
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
[PMID: 32283296]
In Vitro

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CK2 inhibitor 3 Related Antibodies

Cell Viability Assay

Cell Line: Jurkat cells[1]
Concentration: 0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time: 24 hours
Result: Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.

Western Blot Analysis

Cell Line: Jurkat cells[1]
Concentration: 5 μM and 20 μM
Incubation Time: 16 hours
Result: Decreased the CK2-dependent phospho-site Akt Ser129 level.
Molecular Weight

381.20

Formula

C13H9BrN4O3S
CAS No.
SMILES

COC1=CC(/C=C(C(NC2=NN=C(S2)Br)=O)\C#N)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK2 inhibitor 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK2 inhibitor 32979847-14-6Casein KinaseProtein kinase CK2320 protein kinasesCancerCell ViabilityJurkat cellsInhibitorinhibitorinhibit

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CK2 inhibitor 3
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