1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. TMCB

TMCB 

Cat. No.: HY-103384
Handling Instructions

TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively.

For research use only. We do not sell to patients.

TMCB Chemical Structure

TMCB Chemical Structure

CAS No. : 905105-89-7

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Description

TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively[1].

IC50 & Target[1]

CK2α

83 nM (Ki)

CK2α'

21 nM (Ki)

In Vitro

The inhibition of TMCB toward the purified CK2 holoenzyme CK2α2β2 results in a Ki value of 10.1 nM. In addition, Ki values are determined with the surface displayed isoform CK2 holoenzymes and turned out to be of 31.1 nM for CK2α2β2 and 19.6 nM for CK2α'2β2. The surface display of CKα and CK2α', in the context of the corresponding holoenzymes, can be used to identify selective compounds[1].

Molecular Weight

534.82

Formula

C₁₁H₉Br₄N₃O₂

CAS No.

905105-89-7

SMILES

O=C(C1=NCCN1)NC2=C(Br)C(Br)=C(OC)C(Br)=C2Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TMCBCasein KinaseholoenzymeselectiveisoformInhibitorinhibitorinhibit

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